Mari L. DeMarco, PhD

Clinical Associate Professor
Department of Pathology & Laboratory Medicine

Centre for Heart Lung Innovation
Room 166 - 1081 Burrard Street
Vancouver, BC V6Z 1Y6

Phone Number: 
(604) 806-8470
Fax Number: 
(604) 806-9274
Email Address: 

Dr. Mari DeMarco completed her Bachelor of Science degree at Mercyhurst University in Pennsylvania majoring in Honors Biochemistry, minoring in Mathematics, with a concentration in Computational Chemistry. She continued on to a PhD program at the University of Washington to pursue a specialization in Medicinal Chemistry in the Biomolecular Structure and Design Program. Upon graduation, Dr. DeMarco became a Postdoctoral Research Associate at the Complex Carbohydrate Research Centre at the University of Georgia, under the mentorship of Dr. Robert J. Woods. At the Washington University School of Medicine, she undertook a Clinical Chemistry Fellowship with advisor Dr. Jack Ladenson. In 2013, Dr. DeMarco joined the UBC Department of Pathology and Laboratory Medicine as a Clinical Assistant Professor.

Dr. DeMarco is currently a Clinical Associate Professor at the UBC Department of Pathology and Laboratory Medicine, a Principal Investigator at the Centre for Heart Lung Innovation, and a Clinical Chemist at St. Paul's Hospital. Her research is funded by Brain Canada, Alzheimer's Society of BC, Alzheimer's Drug Discovery Foundation, and the Association for Frontotemporal Degeneration. Dr. DeMarco is a Michael Smith Foundation for Health Research Scholar.

Education and Training

  • BSc, Honors Biochemistry (major), Mathematics (minor), Computational Chemistry (concentration), Mercyhurst University
  • PhD, Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington
  • Diplomate of the American Board of Clinical Chemistry
  • Fellow of the Canadian Academy of Clinical Biochemistry

Area of Interest

With a strong interest in bridging basic biomedical science, analytical chemistry, and laboratory medicine, Dr. DeMarco’s research group specializes in new methodological approaches for identification and quantitation of protein biomarkers of health and disease. A particular focus is advancing clinical diagnostics for neurodegenerative disorders, such as Alzheimer’s disease and frontotemporal dementia. This work to translate new biomedical discoveries into patient care is accomplished in collaboration with clinicians and scientists at HLI, the UBC Centre for Brain Health and the provincial Clinic for Alzheimer’s Disease and Related Disorders.

For more information, please visit Dr. DeMarco's laboratory webpage.


Selected Publications