Who we are
We discover and translate innovative solutions for heart, lung, and critical care diseases
Message from the Director
The Centre for Heart Lung Innovation (HLI), previously known as iCAPTURE and the James Hogg Research Centre, was established as the Pulmonary Research Laboratory in 1977 by Drs. James Hogg (2013 Gairdner Wightman Award Winner) and Peter Paré. Since then it has grown dramatically in scope, size, and worldwide impact. Basic and clinician scientists work together in an exciting multidisciplinary environment to address vital issues in heart, lung, and critical care disease. Situated within Providence Health Care’s St. Paul’s Hospital, a University of British Columbia teaching hospital, the HLI is a translational research centre using our basic molecular and cellular research discoveries to develop innovative approaches to prevent and treat human disease through our complementary and connected clinical research.
Our focus is on developing solutions to the biggest challenges: atherosclerosis and heart failure, emphysema and other chronic pulmonary diseases, severe infections such as COVID19 and multiple organ failure. These diseases are leading causes of morbidity, mortality and cost to society in Canada and the world. Combined, these diseases are by far the greatest killers. We seek out the underlying causes so that we can develop strategies for prevention and treatment. We link our basic discoveries to improved health care through clinical research, teaching, and by translating new knowledge into clinical practice at St. Paul’s Hospital and around the world. Since disease involves both the patient and the environment, our focus on prevention seeks to understand and prevent those patient-environment interactions that lead to disease and disability.
The Centre for Heart Lung Innovation has a unique multidisciplinary milieu that takes the best attributes of a busy tertiary care hospital (St. Paul’s) and combines them with the best attributes of a leading academic institution (UBC) to generate novel insight, knowledge, and solutions. It is not uncommon within the HLI to find a mathematician, a pathologist, a surgeon, and a basic scientist, joining forces to attack otherwise intractable problems. We link basic science with clinical innovation; we link a broad knowledge of inflammation with focused investigation into heart, lung, and critical care disease; we link universities, faculties, and departments together to innovate in ways that otherwise are not possible.
Pulmonary Research Laboratories (PRL)
With the support of St. Paul’s Hospital, the University of British Columbia, BC Lung Association, and the Medical Research Council of Canada, the Pulmonary Research Laboratory was established by Drs. James Hogg and Peter Pare.
McDonald Research Laboratories
The PRL is renamed as the McDonald Research Laboratories.
Dr. Bruce McManus, a UBC Professor of Pathology and Laboratory Medicine and cardiac pathologist specializing in heart and blood vessel inflammation, takes over as the Director of iCAPTURE.
New Director of HLI
Dr. Keith Walley, a UBC Professor of Medicine and internationally recognized expert in sepsis and critical care research, takes over as the Director, and the Centre is officially renamed as the Centre for Heart Lung Innovation.
New Director of HLI
Dr. Don Sin, a UBC Professor of Medicine and one of the top experts in chronic obstructive lung disease in the world, takes over as the Director of HLI.
Led by Director Dr. Don Sin and Associate Director Dr. Jordan Guenette, the Centre for Heart Lung Innovation (HLI) now houses 37 Principal Investigators and over 250 students, staff, and faculty members.
New St. Paul's
Together with the rest of St. Paul’s Hospital, the HLI will move to a new site and become an integral part of the Clinical Support and Research Unit (CSRC).