Keith R. Walley, MD

Department of Medicine

Centre for Heart Lung Innovation
St. Paul's Hospital
Room 166 - 1081 Burrard Street
Vancouver, BC V6Z 1Y6

Phone Number: 
(604) 806-8136
Fax Number: 
(604) 806-8351
Email Address: 

Dr. Walley received his MD from the University of Manitoba in 1981, trained in Internal Medicine at McGill University, and subsequently trained in Critical Care Medicine at the University of Chicago. He has been a practicing Intensivist at St. Paul’s Hospital ICU and investigator at the Centre for Heart Lung Innovation since 1988.

Area of Interest

The focus of Dr. Walley's research is to investigate 1) the mechanism of decreased left ventricular contractility and other organ failure during sepsis and 2) the impact of genotype on patient outcomes in sepsis and systemic inflammatory states. Dr. Walley translates basic discoveries into clinical practice in the ICU. Together with Drs. Russell and Boyd, he recently demonstrated that blocking the function of PCSK9, an enzyme that inhibits the clearance of endogenous cholesterol from blood, is associated with increased pathogen clearance via the LDL-receptor, a decreased inflammatory response, and improved septic shock outcome. This important discovery facilitated the emergence of anti-PCSK9 therapies as one of the most promising treatments for sepsis.

Selected Publications