Scott J. Tebbutt, PhD

HLI Education Director | Professor
Department of Medicine

Centre for Heart Lung Innovation
St. Paul's Hospital
Room 166, Burrard Building,
1081 Burrard Street, Vancouver, BC V6Z 1Y6

Phone Number: 
(604) 682-2344 x63051
Fax Number: 
(604) 806-9274
Email Address: 

Scott Tebbutt is a Professor in the Department of Medicine, Division of Respiratory Medicine, University of British Columbia, and Principal Investigator at the Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, Canada. He is the Chief Scientific Officer of the Prevention of Organ Failure (PROOF) Centre of Excellence, a not-for-profit organization dedicated to moving reseach findings into health care, focused on non-invasive biomarkers that can diagnose and/or predict organ failure (heart, lung and kidney).

Dr. Tebbutt earned his B.A. degree in Biochemistry from the University of Oxford (Oriel College), England in 1989, and his Ph.D. in Molecular Genetics from the University of East Anglia in 1993 (supervised by Dr. David Lonsdale, Cambridge Laboratory, John Innes Centre, England). He pursued post-doctoral fellowships in the laboratories of Professor Ann Harris (University of Oxford, Institute of Molecular Medicine) and Professor Diana Hill (University of Otago, Dunedin, New Zealand), where he studied the molecular genetics of cystic fibrosis. He was appointed Research Fellow at the University of Otago (1995-2001), leading a research team investigating the genomics of the sheep cystic fibrosis locus. He was seconded to a start-up biotechnology company (Global Technologies (NZ) Ltd.) as Director of Genomics (1999-2001). He moved to Canada in 2001, and was Senior Researcher in the Centre for Biomedical Research (University of Victoria, 2001-2002), prior to being recruited to the Centre for Heart Lung Innovation (2002).

Dr. Tebbutt has received several fellowships and awards, including an Edward Penley Abraham Research Trust Fellowship (U.K.), a Journal of Cell Science Traveling Fellowship Award, and a Research Fellowship from the Cystic Fibrosis Association of New Zealand. He has been awarded competitive research funding from organizations such as the National Sanitarium Association (Canada), the British Columbia Lung Association, AllerGen NCE Inc. (Allergy, Genes and Environment Network), the Canadian Institutes of Health Research, the BC Proteomics Network, and the Wellcome Trust (U.K.).

Education and Training

  • B.A. Biochemistry, University of Oxford (Orie College), 1989
  • Ph.D. Molecular Genetics, University of East Anglia, 1993

Area of Interest

Dr. Tebbutt’s research programme is focused on systems biology and the use of multi-omics (genomics, transcriptomics, proteomics, metabolomics, etc) to unravel the molecular signatures of complex disease and other health-related conditions, including asthma, allergic rhinitis, heart failure, neonatal vaccinology, and the interaction between spores of the fungus Aspergillus fumigatus with airway epithelial cells. His research combines hypothesis-driven studies of biological mechanisms with the development of advanced tools and technology (including bioinformatics and computational biology) to better facilitate basic and translational research. Dr. Tebbutt has published original research contributions in journals such as Nature Communications, Proceedings of the National Academy of Sciences (U.S.A.), Journal of Medical Genetics, Journal of Asthma, Genomics, BioTechniques, Bioinformatics, BMC Medical Genomics, Proteomics Clinical Applications, PLoS ONE, and Allergy, Asthma & Clinical Immunology. He has published numerous technical reviews as well as book chapters on the role of genetic variation in respiratory disease. He has served as reviewer on several grant panels, including the Canadian Institutes of Health Research and the Michael Smith Foundation for Health Research, and he is Associate Editor for the journal BMC Genetics. He is also a Research Associate of the Peter Wall Institute for Advanced Studies.

Selected Publications