Bruce M. McManus, CM, OBC, MD, PhD

Department of Pathology & Laboratory Medicine

Centre for Heart Lung Innovation
Rm 166 - 1081 Burrard Street

Vancouver, B.C. V6Z 1Y6


Phone Number: 
(604) 806-8586
Email Address: 

Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. He serves as the CEO for Centre of Excellence for Prevention of Organ Failure (PROOF Centre), as Co-Director of the Institute for Heart + Lung Health, and a Past Director, UBC James Hogg Research Centre / Centre for Heart Lung Innovation. Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from 2000 until 2006.
Dr. McManus received BA and MD degrees at the University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo.  He pursued post-doctoral fellowships in Environmental Physiology at the University of California - Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD.  Residency training at the Peter Bent Brigham Hospital - Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology.  After 11 years as a faculty member at the University of Nebraska Medical Centre, including a sabbatical as John F. Fogarty Senior International Fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany, Dr. McManus joined the Faculty of Medicine of the University of British Columbia as Department Head of Pathology and Laboratory Medicine in July 1993, a post he held until December, 2000. Dr. McManus is a Fellow of the Royal College of Physicians and Surgeons of Canada, the College of American Pathologists, the American College of Cardiology, and the American College of Chest Physicians.

Dr. McManus has been recognized for his scientific contributions by numerous institutions and organizations through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award. He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences, elected as an inaugural Fellow of the Canadian Academy of Health Sciences and was honoured with the Research Achievement Award of the Canadian Cardiovascular Society. Dr. McManus has received the BC Innovation Council’s Lieutenant Governor’s Technology Innovation Awardand recognized by the Society for Cardiovascular Pathology with the Distinguished Achievement Award and by Providence Health Care with the Research & Mission Award. He has also received the Milton Wong Leadership Award from LifeSciences BC, the Aubrey J. Tingle Prize from the Michael Smith Foundation for Health Research, and the Alumni Achievement Award from the University of Saskatchewan. In 2018, Dr. McManus was a co-recipient of Margolese National Heart Disorders Prize, and was appointed to the Order of Canada. Dr. McManus was also recently appointed to the Order of British Columbia in 2019.

Education and Training

  • University of Saskatchewan BA Biology and Physical Education, 1963-1967
  • Pennsylvania State University MSc Exercise Physiology, 1967-1969
  • University of Toledo PhD Exercise Physiology and Biochemistry, 1969-1972
  • University of Saskatchewan MD Medicine, 1973-1977
  • Fellow, Royal Society of Canada
  • Fellow, Canadian Academy of Health Sciences
  • Fellow, Royal College of Physicians of Canada
  • Fellow, College of American Pathologists
  • Fellow, American College of Cardiology

Area of Interest

Dr. McManus’ interests focus on mechanisms, consequences, detection and prevention of injury and aberrant repair involved in inflammatory diseases of the heart and blood vessels. He works in a cross-disciplinary setting on translational research questions for which answers are critically enabled by computational sciences, including molecular biomarker discovery and validation, information acquisition, annotation and use, and registry development to support heart and lung research. A major focus continues to be the multi-centre clinical validation of the HEARTBiT rejection-exclusion assay.

Dr. McManus has co-authored >400 peer-reviewed publications and nearly 60 book chapters and 8 patents.  He has edited four books and is a co-holder of numerous patents. He has served as Councilor for the International Society for Heart Research and for the American Society for Investigative Pathology. He is past-president of the Society for Cardiovascular Pathology. He currently serves on editorial boards of several professional and scientific journals, and on many scientific advisory committees and boards. He has long been committed to training and mentoring scientist trainees across a range of disciplines.  He has convened many public and private sector partnerships in research.

Selected Publications