Department of Pathology & Laboratory Medicine

Centre for Heart Lung Innovation
Rm 166 - 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6


Phone Number: 
(604) 806-8586
Email Address: 

Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. He serves as the CEO for Centre of Excellence for Prevention of Organ Failure (PROOF Centre), as Co-Director of the Institute for Heart + Lung Health, and as Immediate-Past Director, UBC James Hogg Research Centre / Centre for Heart Lung Innovation. Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from 2000 until 2006.
Dr. McManus received BA and MD degrees at the University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo.  He pursued post-doctoral fellowships in Environmental Physiology at the University of California - Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD.  Residency training at the Peter Bent Brigham Hospital - Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology.  After 11 years as a faculty member at the University of Nebraska Medical Centre, including a sabbatical as John F. Fogarty Senior International Fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany, Dr. McManus joined the Faculty of Medicine of the University of British Columbia as Department Head of Pathology and Laboratory Medicine in July 1993, a post he held until December, 2000. Dr. McManus is a Fellow of the Royal College of Physicians and Surgeons of Canada, the College of American Pathologists, the American College of Cardiology, and the American College of Chest Physicians.

Dr. McManus’ interests focus on mechanisms, consequences, detection and prevention of injury and aberrant repair involved in inflammatory diseases of the heart and blood vessels. He works in a cross-disciplinary setting where answers are critically enabled by computational sciences. Dr. McManus has co-authored ~365 peer-reviewed publications and >50 chapters.  He has edited four books. He is co-holder of numerous patents. He has served as Councilor for the International Society for Heart Research and for the American Society for Investigative Pathology. He is past-president of the Society for Cardiovascular Pathology. He currently serves on editorial boards of several professional and scientific journals, and on many scientific advisory committees and boards. He has long been committed to training and mentoring scientist trainees across a range of disciplines.  He has convened many public and private sector partnerships in research.

Dr. McManus has been recognized for his scientific contributions by numerous institutions and organizations through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award in 1991.  He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences in 2002.  He received a UBC Killam Research Prize - Senior Scientist Category in 2003.  In 2005, he was elected as an inaugural Fellow of the Canadian Academy of Health Sciences and was honoured with the Research Achievement Award of the Canadian Cardiovascular Society. In 2006 Dr. McManus received the BC Innovation Council’s Lieutenant Governor’s Technology Innovation Award. He has been honored with the 2007 UBC Distinguished Medical Lecturer Award and 2008 David F. Hardwick Lifetime Achievement Award.  He was awarded the 2009 Scientific Excellence Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology. Dr. McManus has been recognized by the Society for Cardiovascular Pathology with the 2010 Distinguished Achievement Award and by Providence Health Care with the 2010 Research & Mission Award. He received the 2012 Milton Wong Leadership Award from LifeSciences BC, the 2012 Aubrey J. Tingle Prize from the Michael Smith Foundation for Health Research, and the 2012 Alumni Achievement Award from the University of Saskatchewan.

Education and Training

  • University of Saskatchewan BA Biology and Physical Education, 1963-1967
  • Pennsylvania State University MSc Exercise Physiology, 1967-1969
  • University of Toledo PhD Exercise Physiology and Biochemistry, 1969-1972
  • University of Saskatchewan MD Medicine, 1973-1977

Selected Publications