NewsQ3 Research Spotlight (July 1st – September 30th, 2023)

In the third quarter of 2023, HLI member Principal Investigators (PIs) authored 89 peer-reviewed articles:

• 48% in respiratory disease
• 31% in cardiovascular disease
• 21% in critical care and other areas

HLI member PIs were first or senior authors on 13 original research articles and 8 meta-analyses or reviews.

See full list below. Here we highlight 8 of these publications:

Publication list:

1. Alqarawi W, Tadros R, Roberts JD, Cheung CC, Green MS, Burwash IG, Steinberg C, Healey JS, Khan H, McIntyre C, Cadrin-Touringy J, Laksman ZWM, Simpson CS, Sanatani S, Gardner M, Angaran P, Ilhan E, Talajic M, Arbour L, Leather R, Seifer C, Joza J, Lee F, Lau L, Nair G, Wells G, Krahn AD. The Prevalence and Characteristics of Arrhythmic Mitral Valve Prolapse in Patients With Unexplained Cardiac Arrest. JACC Clin Electrophysiol. 2023 Sep 6:S2405-500X(23)00630-8. doi: 10.1016/j.jacep.2023.08.017.
2. Bahreyni A, Mohamud Y, Zhang J, Luo H. Engineering a facile and versatile nanoplatform to facilitate the delivery of multiple agents for targeted breast cancer chemo-immunotherapy. Biomed Pharmacother. 2023 Jul;163:114789. doi: 10.1016/j.biopha.2023.114789.
3. Booth S, Hsieh A, Mostaco-Guidolin L, Koo HK, Wu K, Aminazadeh F, Yang CX, Quail D, Wei Y, Cooper JD, Paré PD, Hogg JC, Vasilescu DM, Hackett TL. A Single-Cell Atlas of Small Airway Disease in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study. Am J Respir Crit Care Med. 2023 Aug 15;208(4):472-486. doi: 10.1164/rccm.202303-0534oc
4. Forgrave LM, Moon KM, Hamden JE, Li Y, Lu P, Foster LJ, Mackenzie IRA, DeMarco ML. Truncated TDP-43 proteoforms diagnostic of frontotemporal dementia with TDP-43 pathology. Alzheimers Dement. 2023 Jul 17. doi: 10.1002/alz.13368.
5. Guinto E, Gerayeli FV, Eddy RL, Lee H, Milne S, Sin DD. Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis. Eur Respir Rev. 2023 Aug 9;32(169):220253. doi: 10.1183/16000617.0253-2022.
6. Guo TJF, Singhera GK, Leung JM, Dorscheid DR. Airway Epithelial-Derived Immune Mediators in COVID-19. Viruses. 2023 Jul 29;15(8):1655. doi: 10.3390/v15081655.
7. Heffernan A, Shafiee A, Chan T, Sparanese S, Thamboo A. Non-Type 2 and Mixed Inflammation in Chronic Rhinosinusitis and Lower Airway Disease. Laryngoscope. 2023 Aug 24. doi: 10.1002/lary.30992.
8. Hsieh A, Yang CX, Al-Fouadi M, Nwozor KO, Osei ET, Hackett TL. The contribution of reticular basement membrane proteins to basal airway epithelial attachment, spreading and barrier formation: implications for airway remodeling in asthma. Front Med (Lausanne). 2023 Sep 12;10:1214130. doi: 10.3389/fmed.2023.1214130.
9. Jan-Abu SC, Kabil A, McNagny KM. Parallel origins and functions of T cells and ILCs. Clin Exp Immunol. 2023 Jul 5;213(1):76-86. doi: 10.1093/cei/uxad056.
10. Khor YH, Cottin V, Holland AE, Inoue Y, McDonald VM, Oldham J, Renzoni EA, Russell AM, Strek ME, Ryerson CJ. Treatable traits: a comprehensive precision medicine approach in interstitial lung disease. Eur Respir J. 2023 Jul 27;62(1):2300404. doi: 10.1183/13993003.00404-2023.
11. Kim JV, Assadian S, Hollander Z, Burns P, Shannon CP, Lam K, Toma M, Ignaszewski A, Davies RA, Delgado D, Haddad H, Isaac D, Kim D, Mui A, Rajda M, West L, White M, Zieroth S, Keown PA, McMaster WR, Ng RT, McManus BM, Levings MK, Tebbutt SJ. Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation. Transplantation. 2023 Aug 1;107(8):1810-1819. doi: 10.1097/TP.0000000000004607.
12. Lee T, Cheng MP, Vinh DC, Lee TC, Tran KC, Winston BW, Sweet D, Boyd JH, Walley KR, Haljan G, McGeer A, Lamontagne F, Fowler R, Maslove DM, Singer J, Patrick DM, Marshall JC, Burns KD, Murthy S, Mann PK, Hernandez G, Donohoe K, Russell JA; for ARBs CORONA I. Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave. CMAJ Open. 2023 Aug 1;11(4):E672-E683. doi: 10.9778/cmajo.20220194.
13. Marinescu DC, Hague CJ, Muller NL, Murphy D, Churg A, Wright JL, Al-Arnawoot A, Bilawich AM, Bourgouin P, Cox G, Durand C, Elliot T, Ellis J, Fisher JH, Fladeland D, Grant-Orser A, Goobie GC, Guenther Z, Haider E, Hambly N, Huynh J, Johannson KA, Karjala G, Khalil N, Kolb M, Leipsic J, Lok S, MacIsaac S, McInnis M, Manganas H, Marcoux V, Mayo J, Morisset J, Scallan C, Sedlic T, Shapera S, Sun K, Tan V, Wong AW, Zheng B, Ryerson CJ. Integration and Application of Radiologic Patterns From Clinical Practice Guidelines on Idiopathic Pulmonary Fibrosis and Fibrotic Hypersensitivity Pneumonitis. Chest. 2023 Aug 2:S0012-3692(23)01106-6. doi: 10.1016/j.chest.2023.07.068.
14. Randhawa GK, Orach J, Black A, Chan V, Potter N, Brinkman J, Côté H, Worfolk L, Knight D, Leversage I, Tebbutt SJ. Design, delivery, and evaluation of a knowledge translation intervention for multi-stakeholders. Implement Sci Commun. 2023 Jul 24;4(1):85. doi: 10.1186/s43058-023-00465-9.
15. Robinson A, Huff RD, Ryu MH, Carlsten C. Variants in transient receptor potential channels and toll-like receptors modify airway responses to allergen and air pollution: a randomized controlled response human exposure study. Respir Res. 2023 Sep 7;24(1):218. doi: 10.1186/s12931-023-02518-y.
16. Sin DD. Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know. Tuberc Respir Dis (Seoul). 2023 Jul;86(3):166-175. doi: 10.4046/trd.2023.0015.
17. Steinberg C, Roston TM, van der Werf C, Sanatani S, Chen SRW, Wilde AAM, Krahn AD. RYR2-ryanodinopathies: from calcium overload to calcium deficiency. Europace. 2023 Jun 2;25(6):euad156. doi: 10.1093/europace/euad156.
18. Tajima Y, Seow CY, Dong SJ, Tsutsui M, Cheung CY, Welch I, Mowbray L, Imlach B, Hildebrandt R, Apperloo K, Ryomoto B, Goodacre E, Myrdal C, Machan L, Wolff K, Elizur E, Vasilescu DM, Sin DD. Development of a unilateral porcine emphysema model induced by porcine pancreatic elastase. J Appl Physiol (1985). 2023 Nov 1;135(5):1001-1011. doi: 10.1152/japplphysiol.00801.2022.
19. Turner CT, Zeglinski MR, Boivin W, Zhao H, Pawluk MA, Richardson KC, Chandrabalan A, Bird P, Ramachandran R, Sehmi R, Lima H, Gauvreau G, Granville DJ. Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation. Br J Dermatol. 2023 Aug 24;189(3):279-291. doi: 10.1093/bjd/ljac017.
20. Tzimas G, Gulsin GS, Everett RJ, Akodad M, Meier D, Sewnarain K, Ally Z, Alnamasy R, Ng N, Mullen S, Rotzinger D, Sathananthan J, Sellers SL, Blanke P, Leipsic JA. Age- and Sex-Specific Nomographic CT Quantitative Plaque Data From a Large International Cohort. JACC Cardiovasc Imaging. 2023 Jul 5:S1936-878X(23)00234-6. doi: 10.1016/j.jcmg.2023.05.011.
21. Vasileva D, Greenwood CMT, Daley D. A Review of the Epigenetic Clock: Emerging Biomarkers for Asthma and Allergic Disease. Genes (Basel). 2023 Aug 29;14(9):1724. doi: 10.3390/genes14091724.