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James Hogg Research Laboratories

Don D. Sin, MD, MPH

Canadian Research Chair in Chronic Obstructive Lung Disease
Associate Professor, Department of Medicine, University of British Columbia

UBC James Hogg Research Centre, Institute for Heart + Lung Health
St. Paul’s Hospital, Burrard Building
Room 166 - 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6
Phone: 604-806-8346 (ext. 68395)
Fax: 604-806-9274

Don Sin received his medical degree at University of Alberta, Edmonton, Canada (1991), completed medical residency in general medicine and respiratory medicine at University of Alberta (in 1995) and received a master’s of public health degree at Harvard University, Boston, USA (1997). His first faculty position was as an Assistant Professor of Medicine at University of Alberta in 1999. He was recruited to the University of British Columbia (UBC) in 2004 as a Canada Research Chair in Chronic Obstructive Pulmonary Disease (COPD) and a GlaxoSmithKline/St. Paul’s Foundation Professor of COPD. He is also a senior clinical scholar with the Michael Smith Foundation for Health Research, an Associate Professor of Medicine at UBC, and the Associate Head of Research at UBC Department of Medicine.

He is a staff respirologist at St. Paul’s Hospital in Vancouver and holds several grants as the Principal or co-Principal Investigator all relating to COPD. He has published ~130 peer-reviewed articles and has written numerous editorials and book chapters. His main research focus is to discover novel biomarkers to improve the care and diagnosis of patients with COPD, which currently is the 4th leading cause of death worldwide. Additionally, his laboratory is engaged in projects to better understand why women (especially young women) are particularly vulnerable to COPD and lung cancer. He serves as an editorial board member of several journals including the American Journal of Respiratory and Critical Care Medicine, Chest, European Review for Medical and Pharmacological Sciences Journal, and Clinical Respiratory Journal.

Recent Publications [+]

Publications in Pubmed

Park HY, Man SF, Tashkin D, Wise RA, Connett JE, Anthonisen NA, Sin DD. The Relation of Serum Myeloperoxidase to Disease Progression and Mortality in Patients with Chronic Obstructive Pulmonary Disease (COPD). PLoS One. 2013;8(4):e61315. PMID: 23637811 [PubMed - in process]

Kim WD, Chi HS, Choe KH, Oh YM, Lee SD, Kim KR, Yoo KH, Ngan DA, Elliott WM, Granville DJ, Sin DD, Hogg JC. A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodelling in centrilobular emphysema. Respirology 2013;18:688-696.

Tan WC, Bourbeau J, Hernandez P, Chapman KR, Cowie R, Fitzgerald JM, Aaron S, Marciniuk DD, Maltais F, Buist AS, O'Donnell DE, Sin DD.   Bronchodilator responsiveness and reported respiratory symptoms in an adult population. PLoS One. 2013;8(3):e58932. PMID: 23554960
[PubMed - in process]

van Eeden SF, Sin DD. Oxidative stress in chronic obstructive pulmonary disease: A lung and systemic process.  Can Respir J. 2013 Jan;20(1):27-9. PMID: 23457671 [PubMed - in process]

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A Dynamic Bronchial Airway Gene Expression Signature of COPD and Lung Function Impairment. Am J Respir Crit Care Med. 2013 Mar 7;. [Epub ahead of print], PMID: 23471465 [PubMed - as supplied by publisher]

Sin DD, Van Eeden S, Leipsic J, Man SF. Reply: beneficial effects of angiotensin receptor blockade in chronic obstructive pulmonary disease.  Am J Respir Crit Care Med. 2013 Feb 1;187(3):328. PMID: 23487856 [PubMed - in process]

Winstone TA, Man SF, Hull M, Montaner JS, Sin DD. Epidemic of Lung Cancer in Patients With HIV Infection. Chest. 2013 Feb 1;143(2):305-14. PMID: 23381313 [PubMed - in process]

Kim WD, Chi HS, Choe KH, Oh YM, Lee SD, Kim KR, Yoo KH, Ngan DA, Elliott WM, Sin DD, Hogg JC. A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodeling in centrilobular emphysema. Respirology. 2013 Feb 20;. [Epub ahead of print] PMID: 23421932 [PubMed - as supplied by publisher]

Hao K, Bosse Y, Nickle DC, Pare PD, Postma DS, Laviolette M, Sandford A, Hackett TL, Daley D, Hogg JC, Elliott WM, Couture C, Lamontagne M, Brandsma CA, van den Berge M, Koppelman G, Reicin AS, Nicholson DW, Malkov V, Derry JM, Suver C, Tsou JA, Kulkarni A, Zhang C, Vessey R, Opiteck GJ, Curtis SP, Timens W, Sin DD. Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma. PLoS Genet. 2012 Nov;8(11):e1003029. PMID: 23209423 [PubMed - in process]

Aaron SD, Vandemheen KL, Maltais F, Field SK, Sin DD, Bourbeau J, Marciniuk DD, Fitzgerald JM, Nair P, Mallick R. TNFAlpha antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial. Thorax. 2012 Nov 17;. [Epub ahead of print] PMID: 23161645 [PubMed - as supplied by publisher]

Miyata R, Bai N, Vincent R, Sin DD, Van Eeden SF. Statins Reduce Ambient Particulate Matter (PM10)-Induced Lung Inflammation by Promoting the Clearance of PM10 from Lung Tissues. Chest. 2012 Aug 13;. [Epub ahead of print] PMID: 22910717 [PubMed - as supplied by publisher]

Park HY, Man SF, Sin DD.  Inhaled corticosteroids for chronic obstructive pulmonary disease. BMJ. 2012 Oct 25;345:e6843. PMID: 23100329

Najafzadeh M, Marra CA, Lynd LD, Sadatsafavi M, Fitzgerald JM, McManus B, Sin D. Future Impact of Various Interventions on the Burden of COPD in Canada: A Dynamic Population Model.  PLoS One. 2012;7(10):e46746. PMID: 23071626

Jen R, Rennard SI, Sin DD. Effects of inhaled corticosteroids on airway inflammation in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2012;7:587-95. PMID: 23055709

Hansel NN, Ruczinski I, Rafaels N, Sin DD, Daley D, Malinina A, Huang L, Sandford A, Murray T, Kim Y, Vergara C, Heckbert SR, Psaty BM, Li G, Elliott WM, Aminuddin F, Dupuis J, O'Connor GT, Doheny K, Scott AF, Boezen HM, Postma DS, Smolonska J, Zanen P, Mohamed Hoesein FA, de Koning HJ, Crystal RG, Tanaka T, Ferrucci L, Silverman E, Wan E, Vestbo J, Lomas DA, Connett J, Wise RA, Neptune ER, Mathias RA, Pare PD, Beaty TH, Barnes KC. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD. Hum Genet. 2012 Sep 18;. PMID: 22986903

Zurawska JH, Jen R, Lam S, Coxson HO, Leipsic J, Sin DD. What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screening. Chest. 2012 May;141(5):1147-52. PMID: 22553261

Lee J, Sandford AJ, Connett JE, Yan J, Mui T, Li Y, Daley D, Anthonisen NR, Brooks-Wilson A, Man SF, Sin DD. The Relationship between Telomere Length and Mortality in Chronic Obstructive Pulmonary Disease (COPD). PLoS One 2012;7:e35567.

Van Eeden S, Leipsic J, Man SF, Sin DD. The Relationship Between Lung Inflammation and Cardiovascular Disease. Am J Respir Crit Care Med. 2012 Apr 26;. [Epub ahead of print] PMID: 22538803 [PubMed - as supplied by publisher]

Lehman A, Mattman A, Sin D, Pare P, Zong Z, d'Azzo A, Campos Y, Sirrs S, Hinek A. Emphysema in an adult with galactosialidosis linked to a defect in primary elastic fiber assembly. Mol Genet Metab. 2012 Feb 8.

Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA. The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter. J Allergy Clin Immunol 2012 Jan 7.

Tamagawa E, Bai N, Morimoto K, Gray C, Mui T, Yatera K, Zhang X, Xing L, Li Y, Laher I, Sin DD, Man SF, van Eeden S. Particulate matter induced lung inflammation causes endothelial dysfunction: molecular links. American Journal of Physiology-Lung Cellular and Molecular Physiology (in press).

Sin DD and Sutherland R. Obesity and asthma. Thorax (in press)

Sin DD, Man SFP, McWilliams A, and Lam S. Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer. Chest (in press)

Van Gestel YR, Hoeks SE, Sin DD, Welten GM, Schouten O, Witteveen HJ, Simsek C, Stam H, Mertens FW, van Domburg RT, Poldermans D. The impact of beta1-selective blockers on mortality in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine (accepted)

Van Gestel YR, Hoeks SE, Sin DD, Simsek C, Welten GM, Schouten O, Stam H, Mertens FW, van Domburg RT, Poldermans D. Effect of statin therapy on mortality patients with peripheral arterial disease: a comparison of those with versus without associated chronic obstructive pulmonary disease. American Journal of Cardiology (in press)

Wong AWM, Gan WQ, Burns J, Sin DD, Van Eeden SF. Acute exacerbations of COPD: influence of social factors in determining length of hospital stay and readmission. Canadian Respiratory Journal (in press)

Coxson HO, Quiney B, Sin DD, Xing L, McWilliams AM, Mayo JR, and Lam S. Airway wall thickness assessed using computed tomography and optical coherence tomography. American Journal of Respiratory and Critical Care Medicine 2008;177:1201-6.

Mui TY, Man SFP, and Sin DD*. Developments in drugs for the treatment of chronic obstructive pulmonary disease. Expert Review of Clinical Immunology 2008;4:365-377.

Gan WQ, Ben Zaken-Cohen S, Man SFP, Sin DD*. Sex-related differences in serum cotinine concentrations in daily cigarette smokers. Nicotine and Tobacco Research (in press)

Sin DD, Man SFP, Marciniuk DD, Ford G, FitzGerald M, Wong E, York E, Mainra RR, Ramesh W, Melanka LS, Wilde E, Cowie RL, Williams D, Gan WQ, Rousseau R. The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in COPD. American Journal of Respiratory and Critical Care Medicine 2008;177:1207-14.

O’Donnell DE, Aaron SD, Bourbeau J, Hernandez P, Marciniuk D, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan A, Keenan S, Lacasse Y, Maltais F, Road J, Rocker G, Sin DD, Sinuff T, Voduc N. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease-2008 update- highlights for primary care. Canadian Respiratory Journal 2008;15 (suppl B):1A-8A.

Sin DD*, Pahlavan PS, Man SFP. Surfactant protein D: a lung specific biomarker in COPD? Therapeutic Advances in Respiratory Disease 2008;2:65-74.

Sin DD* and Man SF. Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease. Current Opinion in Pulmonary Disease 2008;14:115-21.

Van Eeden SF and Sin DD. Chronic obstructive pulmonary disease (COPD): a chronic systemic inflammatory disease. Respiration 2008;75:224-38.

Quon B, Gan WQ, Sin DD*. Contemporary management of acute exacerbations of COPD: a systematic review and meta-analysis. Chest 2008;133:756-66.

Briggs A, Spencer M, Wang H, Mannino D, Sin DD. Development and validation of a prognostic index for health outcomes in chronic obstructive pulmonary disease. Archives of Internal Medicine 2008;168:71-9

Sin DD, Man SF. Biomarkers in COPD: are we there yet? (editorial) Chest (in press)
Sin DD. Turning the tide in COPD: smoking cessation. (editorial) Clinical Respiratory Journal  2008;1:1-3.

Sin DD*, Mayo JR. CT scan for atherosclerosis and emphysema: a great hope or a great hype? (editorial) Canadian Journal of Cardiology 2008;24:373-4.

Sin DD*, W. Darlene Reid. Is inflammation good, bad, or irrelevant for skeletal muscles in COPD? (editorial) Thorax 2008;63:95-6.

Sin DD*, Man SF. Interleukin-6: a red herring or a real catch in COPD? (editorial) Chest 2008;133:4-6.