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Heart Lung Innovation

Bruce M. McManus, MD, PhD, FRSC, FCAHS, FRCPC, FCAP, FACC

Professor, UBC Department of Pathology & Laboratory Medicine
Co-Director, Institute for Heart + Lung Health
CEO, Centre of Excellence for Prevention of Organ Failure (PROOF Centre)
St. Paul's Hospital, University of British Columbia
Rm 166 - 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6
James Hogg Research Centre

Elishah Velji, Executive Administrator
Phone: (604) 806-8586
Fax: (604) 806-9274
E-mail: email Elishah Velji

Enter the two words below to reveal the email address 

Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. He serves as the Director of the NCE CECR Centre of Excellence for Prevention of Organ Failure (PROOF Centre), as Co-Director of the Institute for Heart + Lung Health, and as Immediate-Past Director, UBC James Hogg Research Centre. Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from December 2000 until April 2006.
 
Dr. McManus received BA and MD degrees at the University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo.  He pursued post-doctoral fellowships in Environmental Physiology at the University of California - Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD.  Residency training at the Peter Bent Brigham Hospital - Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology.  After 11 years as a faculty member at the University of Nebraska Medical Centre, including a sabbatical as John F. Fogarty Senior International Fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany, Dr. McManus joined the Faculty of Medicine of the University of British Columbia as Department Head of Pathology and Laboratory Medicine in July 1993, a post he held until December, 2000. Dr. McManus is a Fellow of the Royal College of Physicians and Surgeons of Canada, the College of American Pathologists, the American College of Cardiology, and the American College of Chest Physicians.

Dr. McManus’ basic and clinical investigative program is focused on mechanisms, consequences, detection and prevention of injury and aberrant repair involved in inflammatory diseases of the heart and blood vessels, with particular emphasis on enteroviral infections of the heart and transplant vascular disease. He works in a cross-disciplinary setting on translational research questions for which answers are critically enabled by computational sciences including molecular biomarker discovery and validation, information acquisition, annotation, and use, and registry development to support heart and lung research. Dr. McManus has co-authored ~350 peer-reviewed publications, as well as many chapters.  He has edited four books. He is co-holder of numerous patents. He has served as Councilor for the International Society for Heart Research and for the American Society for Investigative Pathology. He is past-president of the Society for Cardiovascular Pathology. He currently serves on editorial boards of several professional and scientific journals, and on many advisory committees and boards. He has long been committed to training and mentoring scientist trainees across a range of disciplines.  He has convened many public and private sector partnerships in research.

Dr. McManus has been recognized for his scientific contributions by numerous institutions and organizations through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award in 1991.  He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences in 2002.  He received a UBC Killam Research Prize - Senior Scientist Category in 2003.  In 2005, he was elected as an inaugural Fellow of the Canadian Academy of Health Sciences and was honoured with the Research Achievement Award of the Canadian Cardiovascular Society. In 2006 Dr. McManus received the BC Innovation Council’s Lieutenant Governor’s Technology Innovation Award. He has been honored with the 2007 UBC Distinguished Medical Lecturer Award and 2008 David F. Hardwick Lifetime Achievement Award.  He was awarded the 2009 CSATVB Scientific Excellence Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology. Dr. McManus has been recognized by the Society for Cardiovascular Pathology with the 2010 Distinguished Achievement Award and by Providence Health Care with the 2010 Research & Mission Award. Recently, he received the 2012 Milton Wong Leadership Award from LifeSciences BC, the 2012 Aubrey J. Tingle Prize from the Michael Smith Foundation for Health Research, and the 2012 Alumni Achievement Award from the University of Saskatchewan.

Dr. McManus has been recognized for his scientific contributions by numerous institutions and organizations through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award in 1991.  He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences in 2002.  He received a UBC Killam Research Prize - Senior Scientist Category in 2003.  In 2005, he was elected as an inaugural Fellow of the Canadian Academy of Health Sciences and was honoured with the Research Achievement Award of the Canadian Cardiovascular Society. In 2006 Dr. McManus received the BC Innovation Council’s Lieutenant Governor’s Technology Innovation Award. He has been honored with the 2007 UBC Distinguished Medical Lecturer Award and 2008 David F. Hardwick Lifetime Achievement Award.  He was awarded the 2009 CSATVB Scientific Excellence Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology. Dr. McManus has been recognized by the Society for Cardiovascular Pathology with the 2010 Distinguished Achievement Award and by Providence Health Care with the 2010 Research & Mission Award. Recently, he received the 2011 Sarrazin Award Lecture from the Canadian Physiological Society.

Education / Training:

  • University of Saskatchewan BA Biology and Physical Education 1963-1967
  • Pennsylvania State University MSc Exercise Physiology 1967-1969
  • University of Toledo PhD Exercise Physiology and Biochemistry 1969-1972
  • University of Saskatchewan MD Medicine 1973-1977


Extra-Degree Training And Experience:

  • University of Saskatchewan, Saskatoon, SK, Canada; President of Students' Physical Education Association, 1966-67; Research Assistant in Child Growth and Development Study, 1966-67
  • Pennsylvania State University, State College, PA; Teaching Graduate Assistant, 1967-68
  • University of Toledo, Toledo, OH; Teaching and Research Graduate Assistant, 1968-71
  • University of California, Santa Barbara, CA, Institute of Environmental Stress; Postgraduate Research Physiologist, 1971-73
  • University of Saskatchewan, Saskatoon, SK, Canada, Medical Student, 1973-77; President of Student Medical Society, 1976-77; Saskatchewan Medical Association Joint Committee on Internship Training, 1976-77; Cardiology and Cardiovascular Pathology electives at University of California, San Diego, 1976
  • Harvard University, Peter Bent Brigham Hospital, Boston, MA, Clinical Fellow in Medicine, Medical House Officer, 1977-78; Clinical Fellow and Resident in Anatomic Pathology 1978-80; Cardiovascular Pathology elective, Children's Hospital Medical Center (Drs. Van Praagh), 1979
  • Somerville Hospital, Somerville, MA, Emergency Room Medical Casualty Officer, 1978-80
  • National Heart, Lung and Blood Institute, Bethesda, MD, Pathology Branch, Senior Staff Fellow, 1980-82
  • American University, Washington DC, Visiting Professor, College of Graduate Studies, Winter-Spring 1982
  • Max Plank Institute for Biochemistry, Martinsried, Germany, John F. Fogarty Senior Fellow, 1989-90
Recent Publications [+]

Publications in Pubmed

Garmaroudi FS, Holmberg KJ, Carthy JM, Bashashati A, Marchant D, Zhang M, Yang D, Janes KA and McManus BM: An ERK–p38 subnetwork coordinates host-cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host Microbe, 13(1) 67-76. Jan 2013.

Hollander Z, Chen V, Lin D, Ng RT, Balshaw R, Cohen Freue GV,  Ignaszewski A, Imai C, Kaan A, Wilson-McManus J, McMaster R, Keown PA, McManus BM. Predicting Acute Cardiac Allograft Rejection Using Donor and Recipient Gene Expression. J Heart Lung Transplant. 2012. [Epub ahead of print]

Gunther OP, Chen V, Freue GC, Balshaw RF, Tebbutt SJ, Hollander Z, Takhar M, McMaster WR, McManus BM, Keown PA, Ng RT. A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers. BMC Bioinformatics 2012;13:326.

Najafzadeh M, Marra CA, Lynd LD, Sadatsafavi M, Fitzgerald JM, McManus B, Sin D. Future Impact of Various Interventions on the Burden of COPD in Canada: A Dynamic Population Model.  PLoS One. 2012;7(10):e46746. PMID: 23071626

Luo H, McManus BM. Is autophagy an avenue to modulate coxsackievirus replication and pathogenesis? Future Microbiol. 2012 Aug;7:921-4. PMID:22913350

Wong BW, Meredith A, Lin D, McManus BM. The Biological Role of Inflammation in Atherosclerosis.
Can J Cardiol. 2012 Sep 14. pii: S0828-282X(12)00326-1. doi: 10.1016/j.cjca.2012.06.023. PMID:22985787

Hawkins AK, Creighton S, Ho A,  McManus B, Hayden MR. Providing Predictive Testing For Huntington Disease Via Telehealth: Results of a Pilot Study In British Columbia, Canada. Clin Genet. 2012 Oct 5;. [Epub ahead of print] PMID: 23039041

Thomas Abraham, Damian Kayra, Bruce McManus, Alex Scott. Quantitative assessment of forward and backward second harmonic three dimensional images of collagen Type I matrix remodeling in a stimulated cellular environment. Available online 15 May 2012.

Shannon CP, Hollander Z, Wilson-McManus J, Balshaw R, Ng RT, McMaster R, McManus BM, Keown PA, Tebbutt SJ. White blood cell differentials enrich whole blood expression data in the context of acute cardiac allograft rejection. Bioinform Biol Insights 2012;6:49-61.

Rahmani M, Carthy JM, McManus BM. Mapping of the Wnt/β-Catenin/TCF Response Elements in the Human Versican Promoter. Methods Mol Biol. 2012;836:35-52.
PMID: 22252626 [PubMed - in process]

Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM. Inflammation in myocardial diseases. Circ Res. 2012 Jan 6;110(1):126-44.
PMID: 22223210 [PubMed - in process]

Liu AC, Lee M, McManus BM, Choy JC. Induction of Endothelial Nitric Oxide Synthase Expression by IL-17 in Human Vascular Endothelial Cells: Implications for Vascular Remodeling in Transplant Vasculopathy.  J Immunol. 2012 Jan 4;. [Epub ahead of print]
PMID: 22219320 [PubMed - as supplied by publisher]

Carthy JM, Luo Z, McManus BM. WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication.
Lab Invest. 2011 Nov 21; PMID: 22105568

Lin D, Hollander Z, Meredith A, Stadnick E, Sasaki M, Cohen Freue G, Qasimi P, Mui A, Ng RT, Balshaw R, Wilson-McManus JE, Wishart D, Hau D, Keown PA, McMaster R, McManus BM.  Molecular signatures of end-stage heart failure. J Card Fail. 2011 Oct;17(10):867-74.

L S Ang, W A Boivin, S J Williams, H Zhao, T Abraham, K Carmine-Simmen, B M McManus,
R C Bleackley and D J Granville. Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm. Cell Death and Disease (2011) 2, e209; doi:10.1038/cddis.2011.88.

Esfandiarei M, Suarez A, Amaral A, Si X, Rahmani M, Dedhar S, McManus BM: Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury. Circ Res99:354-61, 2006.

Rahmani M, Cruz R, Granville DJ, McManus BM: Allograft vasculopathy versus atherosclerosis. Circ Res 99:801-815, 2006.

Si X, Wang Y, Wong J, Zhang J, McManus BM, Luo H: Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication. J Virol  81:3142-50, 2007.

Read JT, Rahmani M, Boroomand S, Allahverdian S, McManus BM, and Rennie PS: Androgen receptor regulation of the versican gene through an androgen response element in the proximal promoter. J Biol Chem, 282:31954-63,2007.

Esfandiarei M, Boroomand S, Suarez A, Si X, Rahmani M, McManus BM: Coxsackievirus B3 activates nuclear factor kappa-B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability. Cell Microbiol, 9:2358-71, 2007.

Cohen Freue G, Hollander Z, Shen E, Zamar R, Balshaw R, Scherer A, McManus BM, Keown P, McMaster R, Ng R. MDQC: A new quality assessment method for microarrays based on quality control reports. Bioinformatics. 23:3162-3163, 2007.

Cheung CT, Marchant D, Walker EKY, Luo H, Luo Z, Zhang J, Yanagawa B, Rahmani M, Cox J, Overall C, Senior R, McManus BM: Ablation of matrix metalloproteinase-9 in coxsackievirus-infected mice increases severity of myocarditis. Circulation 117:1574-1582, 2008.

Burgess B, Naus K, Chan J, Hirsch-Reinshagen V, Tansley G, Matzke L, Chan B, Wilkinson A, Fan J, Donkin J, Balik D, Tanaka T, Ou G, Dyer R, Innis S, McManus BM, Lutjohannn D, Wellington C: Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed apoE-deficient mice. Arterioscler Thromb Vasc Biol. 28:1731-1737, 2008.

Marchant D, Dou Y, Luo H, Garmaroudi FS, McDonough JE, Si X, Walker E, Luo Z, Arner A, Hegele RG, Laher I, McManus BM: Bosentan enhances viral load via endothelin-1 receptor type-A mediated p38 Mitogen-Activated Protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. Circ Res. 104:813-21, 2009.

Marchant D, Sall A, Si X, Abraham T, Wu W, Luo Z, Petersen T, Hegele RG, McManus BM: ERK MAP kinase activated Arf6 trafficking directs CVB3 into an unproductive compartment during virus-host cell entry. J Gen Virol. 90:854-62, 2009.

Marchant D, McManus BM. Matrix metalloproteinases in the pathogenesis of viral heart disease. Trends Cardiovasc Med. 19:21-6, 2009.

Choi HY, Rahmani M, Wong BW, Allahverdian S, McManus BM, Pickering JG, Chan T, Francis GA. ATP-binding cassette transporter a1 expression and apolipoprotein a-i binding are impaired in intima-type arterial smooth muscle cells. Circulation. 119:3223-31, 2009.

Lin D, Hollander Z, Ng R, Imai C, Ignaszewski A, Balshaw R, Cohen-Freue G, Wilson-McManus J, Qasimi P, Meredith A, Mui A, Triche T, McMaster R, Keown PA, McManus BM for the Biomarkers in Transplantation Team and the NCE CECR Centre of Excellence for the Prevention of Organ Failure: Whole blood genomic biomarkers of acute cardiac allograft rejection. J Heart Lung Transplant. 28:927-935, 2009.

Günther OP, Balshaw RF, Scherer A, Hollander Z, Mui A, Triche TJ, Freue GC, Li G, Ng RT, Wilson-McManus J, McMaster WR, McManus BM, Keown PA for the Biomarkers in Transplantation Team. Functional genomic analysis of peripheral blood during early acute renal allograft rejection. Transplantation 88:942-951, 2009.

Wong BW, Rahmani M, Luo Z, Yanagawa B, Wong D, Luo H, McManus BM. Vascular endothelial growth factor increases human cardiac microvascular endothelial cell permeability to low density lipoproteins. J Heart Lung Transplant. 28:950-957, 2009

Watson PH, Wilson-McManus JE, Barnes RO, Giesz SC, Png A, Hegele RG, Brinkman JN, Mackenzie IR, Huntsman DG, Junker A, Gilks B, Skarsgard E, Burgess M, Aparicio S, McManus BM. Evolutionary concepts in biobanking - The BC BioLibrary.  J Transl Med 7:95, 2009.

Abraham T, Carthy J, McManus BM.  Collagen Matrix Remodeling in 3-Dimensional Cellular Space Resolved Using Second Harmonic Generation and Multi Photon Excitation Fluorescence. J Struct Biol 169:36-44, 2010.

Rezai N, Deisher TA, Heine HL, Wang X, Corbel SY, Leung J, Kerjner A, Rossi FMV, Podor TJ, McManus BM: Effects of granulocyte-colony stimulating factor on bone marrow-derived progenitor cells in murine cardiac transplantation. Cardiovasc Pathol. 19:36-47, 2010.

Thiene G, Veinot JP, Angelini A, Baandrup UT, Basso C, Bruneval P, Buja LM, Butany J, d’Amati G, de Gouveia RH, Fallon JT, Fishbein MC, Gallagher PJ, Kholova I, Leone O, McManus B, Rodriguez ER, Schoen FJ, Sheppard MN, Stone JR, van der Wal AC, Winters GL.  AECVP and SCVP 2009 Recommendations for Training in Cardiovascular Pathology.  From the Association for European Cardiovascular Pathology and Society for Cardiovascular Pathology Task Force on Training in Cardiovascular Pathology.  Cardiovasc Pathol 19(3):129-135, 2010.

Keown PA, McMaster WR, McManus BM, for the Biomarkers in Transplantation Program and the PROOF Centre of Excellence. Tools to identify organ rejection and immune quiescence for biological understanding and personalized medical care. Biomark Med 4(1):115-121, 2010.

Freue GV, Sasaki M, Meredith A,  Günther OP, Bergman A, Takhar M, Mui A, Balshaw RF, Ng RT, Opushneva N, Hollander Z, Li G, Borchers C, Wilson-McManus J, McManus BM, Keown PA, McMaster WR. Proteomic signatures in plasma during early acute renal allograft rejection. Mol Cell Proteomics 9(9):1954-1967, 2010.

Marchant D, McManus B. Regulating Viral Myocarditis: Allografted Regulatory T Cells Decrease Immune Infiltration and Viral Load. Circulation 121(24):2609-2611, 2010.

Marchant D, Singhera GK, Utokaparch S, Hacket TL, Boyd JH, Luo Z, Si X, Dorscheid DR, McManus BM, Hegele RG. Toll like receptor 4 mediated p38 mitogen activated protein kinase activation is a determinant of respiratory virus entry and tropism. J Virol 84(21):11359-11373, 2010.
Garmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy KP, Luo H, Janes KA, McManus BM.  Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection. Proc Natl Acad Sci USA 107(39):17053-17058, 2010.

Hollander Z, Lin D, Chen V, Ng R, Wilson-McManus J, Ignaszewski A, Cohen Freue G, Balshaw R, Mui A, McMaster R, Keown PA, McManus BM. Whole Blood Biomarkers of Acute Cardiac Allograft Rejection: Double-Crossing the Biopsy.  Transplantation.  90(12):1388-93, 2010.

Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, Sinelnikov I, Krishnamurthy R, Eisner R, Gautam B, Young N, Xia J, Knox G, Dong E, Huang P, Hollander Z, Pedersen TL, Smith SR, Bamforth F, Greiner R, McManus B, Newman JW, Goodfriend T, Wishart D.  The Human Serum Metabolome.  PLos One 6(2) e16957, 2011.

Carthy JM, Garmaroudi FS, Luo Z, McManus BM. WNT3A induces myofibroblast differentiation by upregulating TGF-beta signaling through SMAD2 in a beta-catenin-dependent manner.  PLoS One 6(5):e19809, 2011.
Carthy JM, Boroomand S, McManus BM. Versican and CD44 in in vitro valvular interstitial cell injury and repair.  Cardiovasc Pathol. 2011 May 3;. [Epub ahead of print]
Wong BW, Wong D, Luo H, McManus BM. Vascular endothelial growth factor-D is overexpressed in human cardiac allograft vasculopathy and diabetic atherosclerosis and induces endothelial permeability to low-density lipoproteins in vitro. J Heart Lung Transplant. (2011 May 25. [Epub ahead of print]).

Luo H, Wong, J, Zhang J, Yanagawa, B, Luo Z, Yang X, Chang, J, McManus B. Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function (In Press 2011).

Selected Recent Chapters:

McManus BM, Allard M, Yanagawa B:  Hemodynamics Disorders. Chapter 7.  Rubin’s Pathology, 5th Edition:  Rubin R, Strayer D (eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2008, pp.229-252.
Esfandiarei M, Yanagawa B, McManus BM:  Single Gene Disorders in Dilated Cardiomyopathy.  Chapter 4.  In: Cardiovascular Genetics and Genomics for the Cardiologist. Liew CC, Dzau V (eds), Blackwell Publishing, Oxford, UK, 2006, pp.55-82.

McManus BM, Lee, CH:  Primary Tumours of the Heart. Chapter 69.  Braunwald’s Heart Disease:  A Textbook of Cardiovascular Medicine, 8th Edition.  Elsevier, Philadelphia, PA, 2007, pp.1815-1827.
Marchant D, Si X, Luo H, McManus BM, Yang DC:  The Impact of CVB3 Infection on Host Cell Biology.  Current Topics in Microbiology and Immunology.  Springer Publications, Heidelberg, Germany, 2006, pp. 177-198.
Moien-Afshari F, Choy J, McManus BM, Laher I: Immunosuppression in Promotion of Cardiac Allograft Vasculopathy. Ed. RR Watson and D. Larson (eds), Blackwell Publishers, Massachusetts, USA, 2007, pp.57-79.

Esfandiarei M, McManus BM: Pathogenesis of Myocarditis. Annual Review of Pathology: Mechanisms of Disease, Volume 3, 2008,pp.127-155.
Carthy J, Heine H, Mui A, McManus BM. The Pathology of Heart Allograft Rejection. Chapter 10. Chronic Allograft Failure: Natural History, Pathogenesis, Diagnosis, and Management. Landes Bioscience, Austin, TX, 2008 [Epub April 2008]

Si X, Marchant D, Yang D, McManus BM, Luo H. The Signaling Duel between Virus and Host: Impact on Coxsackieviral Pathogenesis. Advances in Biochemistry in Health and Disease. Signal Transduction in Cardiovascular System in Health and Disease.  Springer Publications, Montreal, QC, 267-284, 2008.

Lin D, Scherer A, Ng R, Balshaw R, Flynn S, Keown P, McMaster R, McManus BM: Biomarkers in Drug Development: A Handbook of Practice, Appliance, and Strategy. Chapter 19. Clinical Validation and Biomarker Translation. John Wiley & Sons, Inc., February 2010, pp375-398.

 

Walmsley H, Burgess M, Brinkman J, Hegele R, Wilson-McManus J, McManus BM: Biomarkers in Drug Development: A Handbook of Practice, Appliance, and Strategy. Chapter 10. Where Are We Heading/What Do We Really Need? Ethics of biomarkers: where are the borders of investigative research, informed consent and patient protection.  John Wiley & Sons, Inc.  New Jersey, 2010, pp. 625-641.

Burke A, Jendy J. Jr, Lee C, McManus BM, Virmani R. Primary and Secondary Tumors of the Cardiovascular System In: Atlas of Cardiovascular Pathology for the Clinician, Chapter 18. McManus BM (ed), Current Medicine, Philadelphia, PA, 2008, 2nd edition, pp. 275-284. 

 

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