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Heart Lung Innovation

Bruce M. McManus, MD, PhD, FRSC, FCAHS, FRCPC, FCAP, FACC

Professor, UBC Department of Pathology & Laboratory Medicine
Co-Director, Institute for Heart + Lung Health
CEO, Centre of Excellence for Prevention of Organ Failure (PROOF Centre)
St. Paul's Hospital, University of British Columbia
Rm 166 - 1081 Burrard Street, Vancouver, B.C. V6Z 1Y6
James Hogg Research Centre

Elishah Velji, Executive Administrator
Phone: (604) 806-8586
Fax: (604) 806-9274
E-mail: email Elishah Velji

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Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. He serves as the Director of the NCE CECR Centre of Excellence for Prevention of Organ Failure (PROOF Centre), as Co-Director of the Institute for Heart + Lung Health, and as Immediate-Past Director, UBC James Hogg Research Centre. Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from December 2000 until April 2006.
 
Dr. McManus received BA and MD degrees at the University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo.  He pursued post-doctoral fellowships in Environmental Physiology at the University of California - Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD.  Residency training at the Peter Bent Brigham Hospital - Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology.  After 11 years as a faculty member at the University of Nebraska Medical Centre, including a sabbatical as John F. Fogarty Senior International Fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany, Dr. McManus joined the Faculty of Medicine of the University of British Columbia as Department Head of Pathology and Laboratory Medicine in July 1993, a post he held until December, 2000. Dr. McManus is a Fellow of the Royal College of Physicians and Surgeons of Canada, the College of American Pathologists, the American College of Cardiology, and the American College of Chest Physicians.
Dr. McManus’ basic and clinical investigative program is focused on mechanisms, consequences, detection and prevention of injury and aberrant repair involved in inflammatory diseases of the heart and blood vessels, with particular emphasis on enteroviral infections of the heart and transplant vascular disease. He works in a cross-disciplinary setting on translational research questions for which answers are critically enabled by computational sciences including molecular biomarker discovery and validation, information acquisition, annotation, and use, and registry development to support heart and lung research. Dr. McManus has co-authored ~350 peer-reviewed publications, as well as many chapters.  He has edited four books. He is co-holder of numerous patents. He has served as Councilor for the International Society for Heart Research and for the American Society for Investigative Pathology. He is past-president of the Society for Cardiovascular Pathology. He currently serves on editorial boards of several professional and scientific journals, and on many advisory committees and boards. He has long been committed to training and mentoring scientist trainees across a range of disciplines.  He has convened many public and private sector partnerships in research.
Dr. McManus has been recognized for his scientific contributions by numerous institutions and organizations through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award in 1991.  He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences in 2002.  He received a UBC Killam Research Prize - Senior Scientist Category in 2003.  In 2005, he was elected as an inaugural Fellow of the Canadian Academy of Health Sciences and was honoured with the Research Achievement Award of the Canadian Cardiovascular Society. In 2006 Dr. McManus received the BC Innovation Council’s Lieutenant Governor’s Technology Innovation Award. He has been honored with the 2007 UBC Distinguished Medical Lecturer Award and 2008 David F. Hardwick Lifetime Achievement Award.  He was awarded the 2009 CSATVB Scientific Excellence Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology. Dr. McManus has been recognized by the Society for Cardiovascular Pathology with the 2010 Distinguished Achievement Award and by Providence Health Care with the 2010 Research & Mission Award. Recently, he received the 2012 Milton Wong Leadership Award from LifeSciences BC, the 2012 Aubrey J. Tingle Prize from the Michael Smith Foundation for Health Research, and the 2012 Alumni Achievement Award from the University of Saskatchewan.

Education / Training:

  • University of Saskatchewan BA Biology and Physical Education 1963-1967
  • Pennsylvania State University MSc Exercise Physiology 1967-1969
  • University of Toledo PhD Exercise Physiology and Biochemistry 1969-1972
  • University of Saskatchewan MD Medicine 1973-1977

Extra-Degree Training And Experience:

  • University of Saskatchewan, Saskatoon, SK, Canada; President of Students' Physical Education Association, 1966-67; Research Assistant in Child Growth and Development Study, 1966-67
  • Pennsylvania State University, State College, PA; Teaching Graduate Assistant, 1967-68
  • University of Toledo, Toledo, OH; Teaching and Research Graduate Assistant, 1968-71
  • University of California, Santa Barbara, CA, Institute of Environmental Stress; Postgraduate Research Physiologist, 1971-73
  • University of Saskatchewan, Saskatoon, SK, Canada, Medical Student, 1973-77; President of Student Medical Society, 1976-77; Saskatchewan Medical Association Joint Committee on Internship Training, 1976-77; Cardiology and Cardiovascular Pathology electives at University of California, San Diego, 1976
  • Harvard University, Peter Bent Brigham Hospital, Boston, MA, Clinical Fellow in Medicine, Medical House Officer, 1977-78; Clinical Fellow and Resident in Anatomic Pathology 1978-80; Cardiovascular Pathology elective, Children's Hospital Medical Center (Drs. Van Praagh), 1979
  • Somerville Hospital, Somerville, MA, Emergency Room Medical Casualty Officer, 1978-80
  • National Heart, Lung and Blood Institute, Bethesda, MD, Pathology Branch, Senior Staff Fellow, 1980-82
  • American University, Washington DC, Visiting Professor, College of Graduate Studies, Winter-Spring 1982
  • Max Plank Institute for Biochemistry, Martinsried, Germany, John F. Fogarty Senior Fellow, 1989-90
Recent Publications [+]

Publications in Pubmed

Gender-specific plasma proteomic biomarkers in patients with Anderson-Fabry disease. Hollander Z, Dai DL, Putko BN, Yogasundaram H, Wilson-McManus JE, Thompson RB, Khan A, West ML, McManus BM, Oudit GY.Eur J Heart Fail. 2015 Jan 23. doi: 10.1002/ejhf.230. [Epub ahead of print]

Response to letter regarding article, "contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis". Francis GA, Allahverdian S, Cheroudi AC, Abraham T, McManus BM. Circulation. 2015 Jan 20;131(3):e25.

Novel multivariate methods for integration of genomics and proteomics data: applications in a kidney transplant rejection study.Günther OP, Shin H, Ng RT, McMaster WR, McManus BM, Keown PA, Tebbutt SJ, Lê Cao KA. OMICS. 2014 Nov;18(11):682-95.

A role for versican in the development of leiomyosarcoma. Keire PA, Bressler SL, Lemire JM, Edris B, Rubin BP, Rahmani M, McManus BM, van de Rijn M, Wight TN. J Biol Chem. 2014 Dec 5;289(49):34089-103
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A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM. Nat Med. 2014 May;20(5):493-502.

Two-stage, in silico deconvolution of the lymphocyte compartment of the peripheral whole blood transcriptome in the context of acute kidney allograft rejection. Shannon CP, Balshaw R, Ng RT, Wilson-McManus JE, Keown P, McMaster R, McManus BM, Landsberg D, Isbel NM, Knoll G, Tebbutt SJ. PLoS One. 2014 Apr 14;9(4):e95224.
Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion. Shin H, Shannon CP, Fishbane N, Ruan J, Zhou M, Balshaw R, Wilson-McManus JE, Ng RT, McManus BM, Tebbutt SJ; PROOF Centre of Excellence Team. PLoS One. 2014 Mar 7;9(3):e91041.

Proteomic biomarkers of recovered heart function. Hollander Z, Lazárová M, Lam KK, Ignaszewski A, Oudit GY, Dyck JR, Schreiner G, Pauwels J, Chen V, Cohen Freue GV, Ng RT, Wilson-McManus JE, Balshaw R, Tebbutt SJ, McMaster RW, Keown PA, McManus BM; NCE CECR PROOF Prevention of Organ Failure (PROOF) Centre of Excellence. Eur J Heart Fail. 2014 May;16(5):551-9.

Longitudinal analysis of whole blood transcriptomes to explore molecular signatures associated with acute renal allograft rejection. Shin H, Günther O, Hollander Z, Wilson-McManus JE, Ng RT, Balshaw R, Keown PA, McMaster R, McManus BM, Isbel NM, Knoll G, Tebbutt SJ. Bioinform Biol Insights. 2014 Jan 22;8:17-33.

Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Allahverdian S, Chehroudi AC, McManus BM, Abraham T, Francis GA. Circulation. 2014 Apr 15;129(15):1551-9.

Clinical, biochemical, and genetic predictors of coronary artery bypass graft failure. Yanagawa B, Algarni KD, Singh SK, Deb S, Vincent J, Elituv R, Desai ND, Rajamani K, McManus BM, Liu PP, Cohen EA, Radhakrishnan S, Dubbin JD, Schwartz L, Fremes SE. J Thorac Cardiovasc Surg. 2014 Aug;148(2):515-520.e2.

Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. Hiebert PR, Boivin WA, Zhao H, McManus BM, Granville DJ. PLoS One. 2013 Oct 24;8(10):e78939.

Vitamin D in heart failure. Meredith AJ, McManus BM. J Card Fail. 2013 Oct;19(10):692-711.
Alteration of human blood cell transcriptome in uremia. Scherer A, Günther OP, Balshaw RF, Hollander Z, Wilson-McManus J, Ng R, McMaster WR, McManus BM, Keown PA. BMC Med Genomics. 2013 Jun 28;6:23.

Plasma protein biosignatures for detection of cardiac allograft vasculopathy. Lin D, Cohen Freue G, Hollander Z, John Mancini GB, Sasaki M, Mui A, Wilson-McManus J, Ignaszewski A, Imai C, Meredith A, Balshaw R, Ng RT, Keown PA, Robert McMaster W, Carere R, Webb JG, McManus BM; Biomarkers in Transplantation Team; Networks of Centres of Excellence, Centres of Excellence for Commercialization and Research-Prevention of Organ Failure Centre of Excellence. J Heart Lung Transplant. 2013 Jul;32(7):723-33.

Predicting acute cardiac rejection from donor heart and pre-transplant recipient blood gene expression. Hollander Z, Chen V, Sidhu K, Lin D, Ng RT, Balshaw R, Cohen-Freue GV, Ignaszewski A, Imai C, Kaan A, Tebbutt SJ, Wilson-McManus JE, McMaster RW, Keown PA, McManus BM; NCE CECR PROOF Centre of Excellence. J Heart Lung Transplant. 2013 Feb;32(2):259-65.

A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers. Günther OP, Chen V, Freue GC, Balshaw RF, Tebbutt SJ, Hollander Z, Takhar M, McMaster WR, McManus BM, Keown PA, Ng RT. BMC Bioinformatics. 2012 Dec 8;13:326.

The biological role of inflammation in atherosclerosis. Wong BW, Meredith A, Lin D, McManus BM. Can J Cardiol. 2012 Nov-Dec;28(6):631-41.

MicroRNA-203 enhances coxsackievirus B3 replication through targeting zinc finger protein-148. Hemida MG, Ye X, Zhang HM, Hanson PJ, Liu Z, McManus BM, Yang D. Cell Mol Life Sci. 2013 Jan;70(2):277-91.

White blood cell differentials enrich whole blood expression data in the context of acute cardiac allograft rejection. Shannon CP, Hollander Z, Wilson-McManus J, Balshaw R, Ng RT, McMaster R, McManus BM, Keown PA, Tebbutt SJ. Bioinform Biol Insights. 2012;6:49-61.

Mapping of the Wnt/β-catenin/TCF response elements in the human versican promoter. Rahmani M, Carthy JM, McManus BM. Methods Mol Biol. 2012;836:35-52.

Inflammation in myocardial diseases. Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM. Circ Res. 2012 Jan 6;110(1):126-44.

WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication. Carthy JM, Luo Z, McManus BM. Lab Invest. 2012 Feb;92(2):246-55.

Molecular signatures of end-stage heart failure. Lin D, Hollander Z, Meredith A, Stadnick E, Sasaki M, Cohen Freue G, Qasimi P, Mui A, Ng RT, Balshaw R, Wilson-McManus JE, Wishart D, Hau D, Keown PA, McMaster R, McManus BM; Biomarkers in Transplantation Team; NCE CECR PROOF Centre of Excellence. J Card Fail. 2011 Oct;17(10):867-74.

Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm. Ang LS, Boivin WA, Williams SJ, Zhao H, Abraham T, Carmine-Simmen K, McManus BM, Bleackley RC, Granville DJ. Cell Death Dis. 2011 Sep 8;2:e209.

Vascular endothelial growth factor-D is overexpressed in human cardiac allograft vasculopathy and diabetic atherosclerosis and induces endothelial permeability to low-density lipoproteins in vitro. Wong BW, Wong D, Luo H, McManus BM. J Heart Lung Transplant. 2011 Aug;30(8):955-62.

Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner. Carthy JM, Garmaroudi FS, Luo Z, McManus BM. PLoS One. 2011;6(5):e19809.

Versican and CD44 in in vitro valvular interstitial cell injury and repair. Carthy JM, Boroomand S, McManus BM. Cardiovasc Pathol. 2012 Mar-Apr;21(2):74-82.

The other side of arrhythmogenic right ventricular cardiomyopathy. Deyell MW, Andrade JG, McManus BM, Leipsic J. Can J Cardiol. 2011 Mar-Apr;27(2):263.e13-6.

Effects of sample timing and treatment on gene expression in early acute renal allograft rejection. Günther OP, Lin D, Balshaw RF, Ng RT, Hollander Z, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team. Transplantation. 2011 Feb 15;91(3):323-9.

Whole blood biomarkers of acute cardiac allograft rejection: double-crossing the biopsy. Hollander Z, Lin D, Chen V, Ng R, Wilson-McManus J, Ignaszewski A, Cohen Freue G, Balshaw R, Mui A, McMaster R, Keown PA, McManus BM; NCE CECR PROOF Centre of Excellence. Transplantation. 2010 Dec 27;90(12):1388-93
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Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection. Garmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17053-8.

Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. Marchant D, Singhera GK, Utokaparch S, Hackett TL, Boyd JH, Luo Z, Si X, Dorscheid DR, McManus BM, Hegele RG. J Virol. 2010 Nov;84(21):11359-73.

Proteomic signatures in plasma during early acute renal allograft rejection. Freue GV, Sasaki M, Meredith A, Günther OP, Bergman A, Takhar M, Mui A, Balshaw RF, Ng RT, Opushneva N, Hollander Z, Li G, Borchers CH, Wilson-McManus J, McManus BM, Keown PA, McMaster WR; Genome Canada Biomarkers in Transplantation Group. Mol Cell Proteomics. 2010 Sep;9(9):1954-67.

Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Chamberlain CM, Ang LS, Boivin WA, Cooper DM, Williams SJ, Zhao H, Hendel A, Folkesson M, Swedenborg J, Allard MF, McManus BM, Granville DJ. Am J Pathol. 2010 Feb;176(2):1038-49.

Functional genomic analysis of peripheral blood during early acute renal allograft rejection. Günther OP, Balshaw RF, Scherer A, Hollander Z, Mui A, Triche TJ, Freue GC, Li G, Ng RT, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team. Transplantation. 2009 Oct 15;88(7):942-51.

Vascular endothelial growth factor increases human cardiac microvascular endothelial cell permeability to low-density lipoproteins. Wong BW, Rahmani M, Luo Z, Yanagawa B, Wong D, Luo H, McManus BM. J Heart Lung Transplant. 2009 Sep;28(9):950-7.

Whole blood genomic biomarkers of acute cardiac allograft rejection. Lin D, Hollander Z, Ng RT, Imai C, Ignaszewski A, Balshaw R, Freue GC, Wilson-McManus JE, Qasimi P, Meredith A, Mui A, Triche T, McMaster R, Keown PA, McManus BM; Biomarkers in Transplantation Team; NCE CECR Centre of Excellence for the Prevention of Organ Failure. J Heart Lung Transplant. 2009 Sep;28(9):927-35.

ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells. Choi HY, Rahmani M, Wong BW, Allahverdian S, McManus BM, Pickering JG, Chan T, Francis GA. Circulation. 2009 Jun 30;119(25):3223-31.

Matrix metalloproteinases in the pathogenesis of viral heart disease. Marchant D, McManus BM. Trends Cardiovasc Med. 2009 Jan;19(1):21-6.

ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry. Marchant D, Sall A, Si X, Abraham T, Wu W, Luo Z, Petersen T, Hegele RG, McManus BM. J Gen Virol. 2009 Apr;90(Pt 4):854-62.

 

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