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James Hogg Research Laboratories

James C. Hogg MD, PhD.

Emeritus Professor, Department of Pathology and Laboratory Medicine, University of British Columbia
UBC James Hogg Research Centre, Institute for Heart + Lung Health
St. Paul's Hospital
Rm 166 - 1081 Burrard Street,
Vancouver, B.C. V6Z 1Y6

Phone: (604) 806-8346 (ext.62949)
Fax: (604) 806-8351
E-mail: email James Hogg

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Dr. Hogg has been on the Staff of the University of British Columbia located at St. Paul's Hospital since 1977 and is Currently an Emeritus Professor of Pathology at UBC. He earned his medical degree from the University of Manitoba in1962 and a Ph.D. in Experimental Medicine from McGill University in Montreal in 1969 and completed residency training in Anatomic Pathology at the Massachusetts General Hospital and McGill University. He maintains an active Research program focused on the inflammatory process in the lung with particular reference to the structure and function of the lungs in COPD. He works in collaboration with Dr Peter Pare, Dr. Stephan Van Eeden and Dr Shizu Hayashi.


Education / Training:
  • University of Manitoba MD Medicine 1962
  • McGill University Msc Experimental Medicine 1967
  • McGill University PhD Experimental Medicine 1969
  • Massachusetts General Hospital Resident Anatomic Pathology 1969-70
  • McGill University Resident Anatomic Pathology 1970-71

Special Professional Qualifications:

  • Royal College of Physicians & Surgeons FRCP(C) 1974
  • Royal Society of Canada FRSC 1992
  • US National Board of Medical Examiners Diploma 1963
  • Licentiate of the Medical Council of Canada 1963
  • Quebec Licence #72-666 1972
  • B.C. Licence #716 1977
Recent Publications [+]

Publications in Pubmed

Kim WD, Chi HS, Choe KH, Oh YM, Lee SD, Kim KR, Yoo KH, Ngan DA, Elliott WM, Granville DJ, Sin DD, Hogg JC. A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodelling in centrilobular emphysema. Respirology 2013;18:688-696.

Xiang YY, Chen X, Li J, Wang S, Faclier G, Macdonald JF, Hogg JC, Orser BA, Lu WY. Isoflurane Regulates Atypical Type-A gamma-Aminobutyric Acid Receptors in Alveolar Type II Epithelial Cells. Anesthesiology 2013 Mar 12. [Epub ahead of print].

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A Dynamic Bronchial Airway Gene Expression Signature of COPD and Lung Function Impairment. Am J Respir Crit Care Med. 2013 Mar 7;. [Epub ahead of print], PMID: 23471465 [PubMed - as supplied by publisher]

Kim WD, Chi HS, Choe KH, Oh YM, Lee SD, Kim KR, Yoo KH, Ngan DA, Elliott WM, Sin DD, Hogg JC. A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodeling in centrilobular emphysema. Respirology. 2013 Feb 20;. [Epub ahead of print] PMID: 23421932 [PubMed - as supplied by publisher]

Hao K, Bosse Y, Nickle DC, Pare PD, Postma DS, Laviolette M, Sandford A, Hackett TL, Daley D, Hogg JC, Elliott WM, Couture C, Lamontagne M, Brandsma CA, van den Berge M, Koppelman G, Reicin AS, Nicholson DW, Malkov V, Derry JM, Suver C, Tsou JA, Kulkarni A, Zhang C, Vessey R, Opiteck GJ, Curtis SP, Timens W, Sin DD. Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma. PLoS Genet. 2012 Nov;8(11):e1003029. PMID: 23209423 [PubMed - in process]

Brindicci C, Kharitonov SA, Ito M, Elliott MW, Hogg JC, Barnes PJ, Ito K. Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 181(1):21-30. 2010

Gierada DS, Bierhals AJ, Choong CK, Bartel ST, Ritter JH, Das NA, Hong C, Pilgram TK, Bae KT, Whiting BR, Woods JC, Hogg JC, Lutey BA, Battafarano RJ, Cooper JD, Meyers BF, Patterson GA. Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index. Acad Radiol. 17(2):146-156. 2010

Shipley TW, Kling HM, Morris A, Patil S, Kristoff J, Guyach SE, Murphy JE, Shao X, Sciurba FC, Rogers RM, Richards T, Thompson P, Montelaro RC, Coxson HO, Hogg JC, Norris KA. Persistent pneumocystis colonization leads to the development of chronic obstructive pulmonary disease in a nonhuman primate model of AIDS. J Infect Dis. 202(2):302-312. 2010

Gosselink JV, Hayashi S, Elliott WM, Xing L, Chan B, Yang L, Wright C, Sin D, Pare PD, Pierce JA, Pierce RA, Patterson A, Cooper J, Hogg JC. Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 181(12):1329-1335. 2010

Behzad AR, Walker DC, Abraham T, McDonough J, Mahmudi-Azer S, Chu F, Shaheen F, Hogg JC, Pare PD. Localization of DNA and RNA in eosinophil secretory granules. Int Arch Allergy Immunol. 152(1):12-27. 2010

Abraham T, Hogg J. Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence. J Struct Biol. 171(2):189-196. 2010

To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, Elliott WM, Hogg JC, Adcock IM, Barnes PJ. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 182:897-904. 2010

Tranfield EM, van Eeden SF, Yatera K, Hogg JC, Walker DC. Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits. Can J Cardiol.  26(7):e258-269. 2010

Yuan R, Nagao T, Pare PD, Hogg JC, Sin DD, Elliott WM, Loy L, Xing L, Kalloger SE, English JC, Mayo JR, Coxson HO. Quantification of lung surface area using computed tomography. Respir Res. 11:153. 2010

Utokaparch S, Marchant D, Gosselink JV, McDonough JE, Thomas EE, Hogg JC, Hegele RG.  The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department. Pediatr Infect Dis J.  30:e18-23.  2011

van Eeden SF, Hogg JC.  Chronic obstructive pulmonary disease: Do regional differences in tissue inflammation matter? Respiration.  81:359-361. 2011

Steiling K, Berge M, Sebastiani P, O'Connor G, Zhang X, Liu G, Xiao J, Alekseyev Y, Campbell J, Coxson HO, Hogg JC, McWilliams A, Timens W, Hiemstra PS, Sterk PJ, Sin D, Postma D, Lam S, Lenburg ME, Spira A.  Airway gene expression as a molecular phenotype of copd. Proc Am Thorac Soc.  8:208. 2011.

Ling SH, McDonough JE, Gosselink JV, Elliott WM, Hayashi S, Hogg JC, van Eeden SF.  Patterns of retention of particulate matter in lung tissues of copd: Potential role in disease progression. Chest 2011 Jun 9. [Epub ahead of print]