Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.

TitleTripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.
Publication TypeJournal Article
Year of Publication2011
AuthorsZhang, J, Wong, J, Gao, G, Luo, H
JournalFEBS Lett
Volume585
Issue1
Pagination261-5
Date Published2011 Jan 3
ISSN1873-3468
KeywordsAcetylcysteine, Aminopeptidases, Blotting, Western, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Dose-Response Relationship, Drug, Drug Synergism, Enterovirus B, Human, Enzyme Inhibitors, HeLa Cells, Host-Pathogen Interactions, Humans, Leupeptins, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Serine Endopeptidases, Virus Replication
Abstract

The ubiquitin-proteasome system is known to be utilized by coxsackievirus to facilitate its propagation within the host cells. The present study explores the role of tripeptidyl peptidase II (TPPII), a serine peptidase contributing to protein turnover by acting downstream of the proteasome, in regulating coxsackievirus infection. Inhibition of TPPII does not affect virus replication in cells with functional proteasome. However, when the proteasome is impaired, TPPII appears to serve as an alternative to maintain low levels of virus infection. Our results suggest an important function of TPPII in the maintenance of viral growth and may have implications for anti-viral therapy.

DOI10.1016/j.febslet.2010.11.056
Alternate JournalFEBS Lett.
PubMed ID21134372
Grant List92214-1 / / Canadian Institutes of Health Research / Canada
97749-1 / / Canadian Institutes of Health Research / Canada
/ / Canadian Institutes of Health Research / Canada