A rare cardiac neoplasm: case report of cardiac epithelioid angiosarcoma.

TitleA rare cardiac neoplasm: case report of cardiac epithelioid angiosarcoma.
Publication TypeJournal Article
Year of Publication2011
AuthorsMatzke, LAnne Marie, Knowling, MA, Grant, D, Cupples, JB, Leipsic, J, Ignaszewski, A, Allard, MF
JournalCardiovasc Pathol
Date Published2011 Sep-Oct
KeywordsAorta, Abdominal, Atrial Fibrillation, Combined Modality Therapy, Echocardiography, Transesophageal, Epithelioid Cells, Fatal Outcome, Heart Atria, Heart Neoplasms, Hemangiosarcoma, Humans, Male, Middle Aged, Tumor Markers, Biological

Primary cardiac angiosarcoma is a rare neoplasm and the epithelioid variant is exceedingly rare. We report a case of an epithelioid angiosarcoma that involved the right atrium and aorta of a 47-year-old male. The patient presented with atrial fibrillation and presyncopal spells. Following clinical evaluation, including computed tomography scan and trans-esophageal echocardiography, the neoplasm was surgically removed. It was a poorly differentiated malignant neoplasm composed of medium-sized epithelioid cells with a moderate amount of amphophilic cytoplasm. Immunohistochemical staining, including positive staining for CK22, AE1/AE3, melan-A, vimentin, and CD31, indicated the neoplasm was best categorized as an epithelioid angiosarcoma.

Alternate JournalCardiovasc. Pathol.
PubMed ID21081277