Quantification of lung surface area using computed tomography.

TitleQuantification of lung surface area using computed tomography.
Publication TypeJournal Article
Year of Publication2010
AuthorsYuan, R, Nagao, T, Paré, PD, Hogg, JC, Sin, DD, Elliott, MW, Loy, L, Xing, L, Kalloger, SE, English, JC, Mayo, JR, Coxson, HO
JournalRespir Res
Volume11
Pagination153
Date Published2010
ISSN1465-993X
KeywordsAged, Female, Humans, Lung, Male, Middle Aged, Organ Size, Tomography, X-Ray Computed
Abstract

OBJECTIVE: To refine the CT prediction of emphysema by comparing histology and CT for specific regions of lung. To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for comparison with histological measurement of surface area per unit lung volume.METHODS: The histological surface area per unit lung volume was estimated for 140 samples taken from resected lung specimens of fourteen subjects. The region of the lung sampled for histology was located on the pre-operative CT scan; the regional CT median lung density and emphysematous lesion size were calculated using the X-ray attenuation values and a low attenuation cluster analysis. Linear mixed models were used to examine the relationships between histological surface area per unit lung volume and CT measures.RESULTS: The median CT lung density, low attenuation cluster analysis, and the combination of both were important predictors of surface area per unit lung volume measured by histology (p < 0.0001). Akaike's information criterion showed the model incorporating both parameters provided the most accurate prediction of emphysema.CONCLUSION: Combining CT measures of lung density and emphysematous lesion size provides a more accurate estimate of lung surface area per unit lung volume than either measure alone.

DOI10.1186/1465-9921-11-153
Alternate JournalRespir. Res.
PubMed ID21040527
PubMed Central IDPMC2976969
Grant List1P50 HL084948 / HL / NHLBI NIH HHS / United States
R01 HL085096 / HL / NHLBI NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada