Predicting survival across chronic interstitial lung disease: the ILD-GAP model.

TitlePredicting survival across chronic interstitial lung disease: the ILD-GAP model.
Publication TypeJournal Article
Year of Publication2014
AuthorsRyerson, CJ, Vittinghoff, E, Ley, B, Lee, JS, Mooney, JJ, Jones, KD, Elicker, BM, Wolters, PJ, Koth, LL, King, TE, Collard, HR
JournalChest
Volume145
Issue4
Pagination723-8
Date Published2014 Apr
ISSN1931-3543
KeywordsAged, Alveolitis, Extrinsic Allergic, Chronic Disease, Connective Tissue Diseases, Female, Humans, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial, Male, Middle Aged, Models, Theoretical, Prognosis, Survival Rate
Abstract

BACKGROUND: Risk prediction is challenging in chronic interstitial lung disease (ILD) because of heterogeneity in disease-specific and patient-specific variables. Our objective was to determine whether mortality is accurately predicted in patients with chronic ILD using the GAP model, a clinical prediction model based on sex, age, and lung physiology, that was previously validated in patients with idiopathic pulmonary fibrosis.METHODS: Patients with idiopathic pulmonary fibrosis (n=307), chronic hypersensitivity pneumonitis (n=206), connective tissue disease-associated ILD (n=281), idiopathic nonspecific interstitial pneumonia (n=45), or unclassifiable ILD (n=173) were selected from an ongoing database (N=1,012). Performance of the previously validated GAP model was compared with novel prediction models in each ILD subtype and the combined cohort. Patients with follow-up pulmonary function data were used for longitudinal model validation.RESULTS: The GAP model had good performance in all ILD subtypes (c-index, 74.6 in the combined cohort), which was maintained at all stages of disease severity and during follow-up evaluation. The GAP model had similar performance compared with alternative prediction models. A modified ILD-GAP Index was developed for application across all ILD subtypes to provide disease-specific survival estimates using a single risk prediction model. This was done by adding a disease subtype variable that accounted for better adjusted survival in connective tissue disease-associated ILD, chronic hypersensitivity pneumonitis, and idiopathic nonspecific interstitial pneumonia.CONCLUSION: The GAP model accurately predicts risk of death in chronic ILD. The ILD-GAP model accurately predicts mortality in major chronic ILD subtypes and at all stages of disease.

DOI10.1378/chest.13-1474
Alternate JournalChest
PubMed ID24114524