Optimizing Cholesterol Treatment in Patients with Muscle Complaints

TitleOptimizing Cholesterol Treatment in Patients with Muscle Complaints
Publication TypeJournal Article
Year of Publication2017
AuthorsRosenson, RS, Baker, S, Banach, M, Borow, KM, Braun, LT, Bruckert, E, Brunham, LR, Catapano, AL, Elam, MB, Mancini, GBJ, Moriarty, PM, Morris, PB, Muntner, P, Ray, KK, Stroes, ES, Taylor, BA, Taylor, VH, Watts, GF, Thompson, PD
JournalJournal of the American College of Cardiology
Volume70
Issue10
Pagination1290-1301
Date Published09/2017
ISSNPrint: 0735-1097; Online: 1558-3597
Abstract

Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms.

DOI10.1016/j.jacc.2017.07.752