The meta-genome of sepsis: host genetics, pathogens and the acute immune response.

TitleThe meta-genome of sepsis: host genetics, pathogens and the acute immune response.
Publication TypeJournal Article
Year of Publication2014
AuthorsBoyd, JH, Russell, JA, Fjell, CD
JournalJ Innate Immun
Volume6
Issue3
Pagination272-83
Date Published2014
ISSN1662-8128
Abstract

Severe infection and the patient response constitute sepsis. Here, we review the meta-genome (patient genetics, pathogen communities and host response) and its impact upon the outcome of severe sepsis. Patient genetics, both predisposition for infection and the subsequent response to infection are reviewed. The pathogen is discussed with particular emphasis upon the modern era of microbiome analysis and nucleic acid diagnostics. Finally, we discuss the host clinical and immune responses and present new data to suggest that the immune response is the key to understanding sepsis and improving a death rate of nearly 30%.

DOI10.1159/000358835
Alternate JournalJ Innate Immun
PubMed ID24525633
Grant List / / Canadian Institutes of Health Research / Canada