Longer telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.

TitleLonger telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.
Publication TypeJournal Article
Year of Publication2014
AuthorsSaferali, A, Lee, J, Sin, DD, Rouhani, FN, Brantly, ML, Sandford, AJ
JournalPLoS One
Volume9
Issue4
Paginatione95600
Date Published2014
ISSN1932-6203
Abstract

Oxidative stress is involved in the pathogenesis of airway obstruction in α1-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence. To test whether telomere length differs in α1-antitrypsin deficient patients compared with controls, we measured telomere length in DNA from peripheral blood cells of 217 α1-antitrypsin deficient patients and 217 control COPD patients. We also tested for differences in telomere length between DNA from blood and DNA from lung tissue in a subset of 51 controls. We found that telomere length in the blood was significantly longer in α1-antitrypsin deficient COPD patients compared with control COPD patients (p = 1×10(-29)). Telomere length was not related to lung function in α1-antitrypsin deficient patients (p = 0.3122) or in COPD controls (p = 0.1430). Although mean telomere length was significantly shorter in the blood when compared with the lungs (p = 0.0078), telomere length was correlated between the two tissue types (p = 0.0122). Our results indicate that telomere length is better preserved in α1-antitrypsin deficient COPD patients than in non-deficient patients. In addition, measurement of telomere length in the blood may be a suitable surrogate for measurement in the lung.

DOI10.1371/journal.pone.0095600
Alternate JournalPLoS ONE
PubMed ID24763308
PubMed Central IDPMC3998943