Title | Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Gibb, EA, Enfield, KSS, Stewart, GL, Lonergan, KM, Chari, R, Ng, RT, Zhang, L, MacAulay, CE, Rosin, MP, Lam, WL |
Journal | Oral Oncol |
Volume | 47 |
Issue | 11 |
Pagination | 1055-61 |
Date Published | 2011 Nov |
ISSN | 1879-0593 |
Keywords | Chromosome Mapping, Gene Expression Profiling, Humans, Mouth Diseases, Mouth Mucosa, Mouth Neoplasms, Precancerous Conditions, RNA, Untranslated |
Abstract | Oral epithelial dysplasias are believed to progress through a series of histopathological stages; from mild to severe dysplasia, to carcinoma in situ, and finally to invasive OSCC. Underlying this change in histopathological grade are gross chromosome alterations and changes in gene expression of both protein-coding genes and non-coding RNAs. Recent papers have described associations of aberrant expression of microRNAs, one class of non-coding RNAs, with oral cancer. However, expression profiling of long non-coding RNAs (lncRNAs) has not been reported. Long non-coding RNAs are a novel class of mRNA-like transcripts with no protein coding capacity, but with a variety of functions including roles in epigenetics and gene regulation. In recent reports, the aberrant expression of lncRNAs has been associated with human cancers, suggesting a critical role in tumorigenesis. Here, we present the first long non-coding RNA expression map for the human oral mucosa. We describe the expression of 325 long non-coding RNAs, suggesting lncRNA expression contributes significantly to the oral transcriptome. Intriguingly, ∼60% of the detected lncRNAs show aberrant expression in oral premalignant lesions. A number of these lncRNAs have been previously associated with other human cancers. |
DOI | 10.1016/j.oraloncology.2011.07.008 |
Alternate Journal | Oral Oncol. |
PubMed ID | 21835683 |
Grant List | 2R01 CA103830-6A1 / CA / NCI NIH HHS / United States MOP 77903 / / Canadian Institutes of Health Research / Canada MOP 86731 / / Canadian Institutes of Health Research / Canada R01DE13124 / DE / NIDCR NIH HHS / United States R01DE15965 / DE / NIDCR NIH HHS / United States R01DE17013 / DE / NIDCR NIH HHS / United States |