Interplay between the cellular autophagy machinery and positive-stranded RNA viruses.

TitleInterplay between the cellular autophagy machinery and positive-stranded RNA viruses.
Publication TypeJournal Article
Year of Publication2012
AuthorsShi, J, Luo, H
JournalActa Biochim Biophys Sin (Shanghai)
Volume44
Issue5
Pagination375-84
Date Published2012 May
ISSN1745-7270
KeywordsAutophagy, Hepacivirus, Humans, Immunity, Innate, Lipid Metabolism, Microtubule-Associated Proteins, Phagosomes, Poliovirus, RNA Viruses, Signal Transduction, Small Ubiquitin-Related Modifier Proteins, TOR Serine-Threonine Kinases, Unfolded Protein Response, Viral Nonstructural Proteins, Virus Replication
Abstract

Autophagy is a conserved cellular process that acts as a key regulator in maintaining cellular homeostasis. Recent studies implicate an important role for autophagy in infection and immunity by removing invading pathogens and through modulating innate and adaptive immune responses. However, several pathogens, notably some positive-stranded RNA viruses, have subverted autophagy to their own ends. In this review, we summarize the current understanding of how viruses with a positive-stranded RNA genome interact with the host autophagy machinery to control their replication and spread. We review the mechanisms underlying the induction of autophagy and discuss the pro- and anti-viral functions of autophagy and the potential mechanisms involved.

DOI10.1093/abbs/gms010
Alternate JournalActa Biochim. Biophys. Sin. (Shanghai)
PubMed ID22343377
Grant List92214-1 / / Canadian Institutes of Health Research / Canada
97749-1 / / Canadian Institutes of Health Research / Canada
/ / Canadian Institutes of Health Research / Canada