HDL as a Causal Factor in Atherosclerosis: Insights from Human Genetics

TitleHDL as a Causal Factor in Atherosclerosis: Insights from Human Genetics
Publication TypeJournal Article
Year of Publication2016
AuthorsBrunham, LR
JournalCurrent Atherosclerosis Reports
Volume18
Issue12
Start Page71
Date Published12/2016
ISSNPrint: 1523-3804; Online: 1534-6242
Abstract

High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current state of knowledge regarding genetically determined HDL-C levels and ASCVD risk and determine what insight these studies provide into the causal relationship between HDL and atherosclerosis.

DOI10.1007/s11883-016-0623-0