| Title | HDL as a Causal Factor in Atherosclerosis: Insights from Human Genetics |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Brunham, LR |
| Journal | Current Atherosclerosis Reports |
| Volume | 18 |
| Issue | 12 |
| Start Page | 71 |
| Date Published | 12/2016 |
| ISSN | Print: 1523-3804; Online: 1534-6242 |
| Abstract | High-density lipoprotein cholesterol (HDL-C) levels are inversely related to risk of atherosclerotic cardiovascular disease (ASCVD). However, the simplistic assumption that HDL-C levels directly and causally impact atherogenesis has been challenged in recent years. The purpose of this article is to review the current state of knowledge regarding genetically determined HDL-C levels and ASCVD risk and determine what insight these studies provide into the causal relationship between HDL and atherosclerosis. |
| DOI | 10.1007/s11883-016-0623-0 |