Granzymes in age-related cardiovascular and pulmonary diseases.

TitleGranzymes in age-related cardiovascular and pulmonary diseases.
Publication TypeJournal Article
Year of Publication2010
AuthorsHendel, A, Hiebert, PR, Boivin, WA, Williams, SJ, Granville, DJ
JournalCell Death Differ
Volume17
Issue4
Pagination596-606
Date Published2010 Apr
ISSN1476-5403
KeywordsAging, Animals, Autoimmune Diseases, Blood Vessels, Bronchi, Cardiovascular Diseases, Extracellular Matrix, Granzymes, Humans, Inflammation, Inflammation Mediators, Lung Diseases
Abstract

Chronic inflammation is a hallmark of age-related cardiovascular and pulmonary diseases. Granzymes are a family of serine proteases that have been traditionally viewed as initiators of immune-mediated cell death. However, recent findings suggest that the pathophysiological role of granzymes is complex. Emerging functions for granzymes in extracellular matrix degradation, autoimmunity, and inflammation suggests a multifactorial mechanism by which these enzymes are capable of mediating tissue damage. Recent discoveries showing that granzymes can be produced and secreted by nonimmune cells during disease provide an additional layer of intricacy. This review examines the emerging biochemical and clinical evidence pertaining to intracellular and/or extracellular granzymes in the pathogenesis of aging and cardiopulmonary diseases.

DOI10.1038/cdd.2010.5
Alternate JournalCell Death Differ.
PubMed ID20139894
Grant List / / Canadian Institutes of Health Research / Canada