Granzyme B in injury, inflammation, and repair.

TitleGranzyme B in injury, inflammation, and repair.
Publication TypeJournal Article
Year of Publication2012
AuthorsHiebert, PR, Granville, DJ
JournalTrends Mol Med
Volume18
Issue12
Pagination732-41
Date Published2012 Dec
ISSN1471-499X
KeywordsExtracellular Matrix Proteins, Granzymes, Humans, Inflammation, Models, Biological, Skin Aging, Substrate Specificity, Wound Healing
Abstract

Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B is observed during prolonged inflammation and is implicated in the pathogenesis of several chronic inflammatory diseases. Although its role in cytotoxic lymphocyte-mediated apoptosis is well established, granzyme B can also degrade extracellular matrix proteins and alter inflammation if present in the extracellular milieu. The present review focuses on the emerging evidence for the involvement of granzyme B in chronic inflammation, impaired wound healing, and age-related skin fragility.

DOI10.1016/j.molmed.2012.09.009
Alternate JournalTrends Mol Med
PubMed ID23099058
Grant List / / Canadian Institutes of Health Research / Canada