Title | Granzyme B in injury, inflammation, and repair. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Hiebert, PR, Granville, DJ |
Journal | Trends Mol Med |
Volume | 18 |
Issue | 12 |
Pagination | 732-41 |
Date Published | 2012 Dec |
ISSN | 1471-499X |
Keywords | Extracellular Matrix Proteins, Granzymes, Humans, Inflammation, Models, Biological, Skin Aging, Substrate Specificity, Wound Healing |
Abstract | Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B is observed during prolonged inflammation and is implicated in the pathogenesis of several chronic inflammatory diseases. Although its role in cytotoxic lymphocyte-mediated apoptosis is well established, granzyme B can also degrade extracellular matrix proteins and alter inflammation if present in the extracellular milieu. The present review focuses on the emerging evidence for the involvement of granzyme B in chronic inflammation, impaired wound healing, and age-related skin fragility. |
DOI | 10.1016/j.molmed.2012.09.009 |
Alternate Journal | Trends Mol Med |
PubMed ID | 23099058 |
Grant List | / / Canadian Institutes of Health Research / Canada |