|Title||GOLD 2017 classification and lung function decline in chronic obstructive pulmonary disease|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Tan, WC, Bourbeau, J, Aaron, SD, Zhou, G, Maltais, F, Hernandez, P, Fitzgerald, JM, Marciniuk, DD, Walker, BL, Sin, D|
|Journal||American Journal of Respiratory and Critical Care Medicine|
|ISSN||Print: 0959-8138; Online: 1756-1833|
Scientific Knowledge on the Subject: The Global Initiative for Obstructive Lung Disease (GOLD) introduced a refinement of the GOLD 2011 ABCD classification for the management of COPD in 2017. It is unknown how this new classification affects therapeutic assignments and whether it is related to clinical outcomes such as lung function decline.
What this Study adds to the Field: Our analysis of a large group of individuals with COPD selected from the general population shows that the refined multicomponent 2017 GOLD A-D classification based solely on patientoriented responses provides a simpler classification compared with the 2011 GOLD classification and results in reassigning COPD subjects to less severe disease categories that require reduced therapy. Our findings substantiate the role of symptom burden or health status in predicting the progression of disease independent of the level of baseline lung function.