Ethnic variation in fat and lean body mass and the association with insulin resistance.

TitleEthnic variation in fat and lean body mass and the association with insulin resistance.
Publication TypeJournal Article
Year of Publication2009
AuthorsLear, SA, Kohli, S, Bondy, GP, Tchernof, A, Sniderman, AD
JournalJ Clin Endocrinol Metab
Volume94
Issue12
Pagination4696-702
Date Published2009 Dec
ISSN1945-7197
KeywordsAdipose Tissue, Adult, Age Factors, Anthropometry, Asia, Southeastern, Asian Continental Ancestry Group, Body Composition, Canada, China, Ethnic Groups, European Continental Ancestry Group, Female, Humans, Indians, North American, Insulin, Insulin Resistance, Life Style, Male, Middle Aged, Regression Analysis, Sex Factors, Socioeconomic Factors
Abstract

CONTEXT: Body fat distribution varies among different ethnic groups, yet less is known regarding differences in lean mass and how this may affect insulin resistance.OBJECTIVE: Our objective was to compare total body fat to lean mass ratio (F:LM) in Aboriginal, Chinese, European, and South Asian individuals with differences in insulin resistance.PARTICIPANTS, DESIGN, AND SETTING: Aboriginal (196), Chinese (222), European (202), and South Asian (208) individuals were recruited across a range of body mass index to participate in this cross-sectional community study.MAIN OUTCOME MEASURES: Total body fat, lean mass, and insulin resistance were assessed using homeostasis model assessment (HOMA).RESULTS: After adjustment for confounders and at a given body fat, South Asian men had less lean mass than Aboriginal [3.42 kg less; 95% confidence interval (CI) = 1.55-5.29], Chinese (3.01 kg less; 95% CI = 1.33-4.70), and European (3.57 kg less; 95% CI = 1.82-5.33) men, whereas South Asian women had less lean mass than Aboriginal (1.98 kg less; 95% CI = 0.45-3.50), Chinese (2.24 kg less; 95% CI = 0.81-3.68), and European (2.97 kg less; 95% CI = 1.67-4.27) women. In adjusted models, F:LM was higher in South Asian compared with Chinese and European men and higher in South Asian compared with Aboriginal, Chinese, and European women (P < 0.01 for all). Insulin and HOMA were greatest in South Asians after adjustment; however, these differences were no longer apparent when F:LM was considered.CONCLUSIONS: South Asians have a phenotype of high fat mass and low lean mass, which may account for greater levels of insulin and HOMA compared with other ethnic groups.

DOI10.1210/jc.2009-1030
Alternate JournalJ. Clin. Endocrinol. Metab.
PubMed ID19820012
Grant List / / Canadian Institutes of Health Research / Canada