Epidemic of lung cancer in patients with HIV infection.

TitleEpidemic of lung cancer in patients with HIV infection.
Publication TypeJournal Article
Year of Publication2013
AuthorsWinstone, TA, Man, SFPaul, Hull, M, Montaner, JS, Sin, DD
JournalChest
Volume143
Issue2
Pagination305-14
Date Published2013 Feb 1
ISSN1931-3543
KeywordsEpidemics, HIV Infections, Humans, Incidence, Lung Neoplasms, Prognosis, Risk Factors, Smoking
Abstract

The survival of patients with HIV infection has improved dramatically over the past 20 years, largely owing to a significant reduction in opportunistic infections and AIDs-defining malignancies, such as lymphoma and Kaposi sarcoma. However, with improved survival, patients with HIV are experiencing morbidity and mortality from other (non-AIDs-defining) complications, such as solid organ malignancies. Of these, the leading cause of mortality in the HIV-infected population is lung cancer, accounting for nearly 30% of all cancer deaths and 10% of all non-HIV-related deaths. Importantly, the average age of onset of lung cancer in the HIV-infected population is 25 to 30 years earlier than that in the general population and at lower exposure to cigarette smoke. This article provides an overview of the epidemiology of lung cancer in the HIV-infected population and discusses some of the important risk factors and pathways that may enhance the risk of lung cancer in this population.

DOI10.1378/chest.12-1699
Alternate JournalChest
PubMed ID23381313
PubMed Central IDPMC3619638
Grant ListR01-DA-03104301 / DA / NIDA NIH HHS / United States