Title | Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Hill, J, Heslop, C, Man, SFPaul, Frohlich, J, Connett, JE, Anthonisen, NR, Wise, RA, Tashkin, DP, Sin, DD |
Journal | Eur Heart J |
Volume | 32 |
Issue | 15 |
Pagination | 1918-25 |
Date Published | 2011 Aug |
ISSN | 1522-9645 |
Keywords | Adult, Biological Markers, Cardiovascular Diseases, Chronic Disease, Cohort Studies, Female, Hospitalization, Humans, Interleukin-6, Male, Middle Aged, Pneumonia, Prognosis, Pulmonary Surfactant-Associated Protein D, Risk Factors, ROC Curve |
Abstract | AIMS: Surfactant protein-D (SP-D) is a lung-specific protein that is detectable in human plasma. We determined the relationship of circulating SP-D to cardiovascular disease (CVD) and total mortality in subjects with and without CVD. METHODS AND RESULTS: Plasma SP-D levels were measured in 806 patients who underwent coronary angiography to assess its predictive value for cardiovascular mortality. Serum SP-D levels were also measured in a replication cohort to assess its relationship with CVD events in 4468 ex- and current smokers without a known history of coronary artery disease (CAD). Patients who died during follow-up had significantly higher plasma SP-D levels than those who survived (median 85.4 vs. 64.8 ng/mL; P < 0.0001). Those in the highest quintile of SP-D had 4.4-fold higher risk of CVD mortality than those in the lowest quintile (P < 0.0001) independent of age, sex, and plasma lipid levels. In a group of current and ex-smokers without a known history of CAD, serum SP-D levels were elevated in those who died or were hospitalized for CVD compared with those who did not (median 99.8 vs. 90.6 ng/mL; P = 0.0001). CONCLUSION: Circulating SP-D is a good predictor of cardiovascular morbidity and mortality and adds prognostic information to well-established risk factors such as age, sex, and plasma lipids and is a promising biomarker to link lung inflammation/injury to CVD. |
DOI | 10.1093/eurheartj/ehr124 |
Alternate Journal | Eur. Heart J. |
PubMed ID | 21653561 |
Grant List | / / Canadian Institutes of Health Research / Canada |