Cholesterol in islet dysfunction and type 2 diabetes.

TitleCholesterol in islet dysfunction and type 2 diabetes.
Publication TypeJournal Article
Year of Publication2008
AuthorsBrunham, LR, Kruit, JK, C Verchere, B, Hayden, MR
JournalJ Clin Invest
Volume118
Issue2
Pagination403-8
Date Published2008 Feb
ISSN0021-9738
KeywordsAnimals, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters, Cholesterol, Diabetes Mellitus, Type 2, Glucose, Humans, Islets of Langerhans, Mice
Abstract

Type 2 diabetes (T2D) frequently occurs in the context of abnormalities of plasma lipoproteins. However, a role for elevated levels of plasma cholesterol in the pathogenesis of this disease is not well established. Recent evidence suggests that alterations of plasma and islet cholesterol levels may contribute to islet dysfunction and loss of insulin secretion. A number of genes involved in lipid metabolism have been implicated in T2D. Recently an important role for ABCA1, a cellular cholesterol transporter, has emerged in regulating cholesterol homeostasis and insulin secretion in pancreatic beta cells. Here we review the impact of cholesterol metabolism on islet function and its potential relationship to T2D.

DOI10.1172/JCI33296
Alternate JournalJ. Clin. Invest.
PubMed ID18246189
PubMed Central IDPMC2214697