Title | Caveolin as a potential drug target for cardiovascular protection |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Sellers, SL, Trane, AE, Bernatchez, PN |
Journal | Frontiers in Physiology |
Volume | 3 |
Issue | 280 |
Date Published | 07/2012 |
ISSN | 1664-042X |
Abstract | Caveolae and caveolin are key players in a number of disease processes. Current research indicates that caveolins play a significant role in cardiovascular disease and dysfunction. The far-reaching roles of caveolins in disease and dysfunction make them particularly notable therapeutic targets. In particular, caveolin-1 (Cav-1) and caveolin-3 (Cav-3) have been identified as potential regulators of vascular dysfunction and heart disease and might even confer cardiac protection in certain settings. Such a central role in vascular health therefore makes manipulation of Cav-1/3 function or expression levels clear therapeutic targets in a variety of cardiovascular related disease states. Here, we highlight the role of Cav-1 and Cav-3 in cardiovascular health and explore the potential of Cav-1 and Cav-3 derived experimental therapeutics. |
DOI | 10.3389/fphys.2012.00280 |