Caveolin as a potential drug target for cardiovascular protection

TitleCaveolin as a potential drug target for cardiovascular protection
Publication TypeJournal Article
Year of Publication2012
AuthorsSellers, SL, Trane, AE, Bernatchez, PN
JournalFrontiers in Physiology
Volume3
Issue280
Date Published07/2012
ISSN1664-042X
Abstract

Caveolae and caveolin are key players in a number of disease processes. Current research indicates that caveolins play a significant role in cardiovascular disease and dysfunction. The far-reaching roles of caveolins in disease and dysfunction make them particularly notable therapeutic targets. In particular, caveolin-1 (Cav-1) and caveolin-3 (Cav-3) have been identified as potential regulators of vascular dysfunction and heart disease and might even confer cardiac protection in certain settings. Such a central role in vascular health therefore makes manipulation of Cav-1/3 function or expression levels clear therapeutic targets in a variety of cardiovascular related disease states. Here, we highlight the role of Cav-1 and Cav-3 in cardiovascular health and explore the potential of Cav-1 and Cav-3 derived experimental therapeutics.

DOI10.3389/fphys.2012.00280