Antielastin autoimmunity in tobacco smoking-induced emphysema.

TitleAntielastin autoimmunity in tobacco smoking-induced emphysema.
Publication TypeJournal Article
Year of Publication2007
AuthorsLee, S-H, Goswami, S, Grudo, A, Song, L-Z, Bandi, V, Goodnight-White, S, Green, L, Hacken-Bitar, J, Huh, J, Bakaeen, F, Coxson, HO, Cogswell, S, Storness-Bliss, C, Corry, DB, Kheradmand, F
JournalNat Med
Volume13
Issue5
Pagination567-9
Date Published2007 May
ISSN1078-8956
KeywordsAutoimmunity, B-Lymphocytes, Elastin, Emphysema, Humans, Lung, Pulmonary Disease, Chronic Obstructive, Smoking, T-Lymphocytes, T-Lymphocytes, Regulatory
Abstract

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

DOI10.1038/nm1583
Alternate JournalNat. Med.
PubMed ID17450149