Airway epithelial barrier function regulates the pathogenesis of allergic asthma.

TitleAirway epithelial barrier function regulates the pathogenesis of allergic asthma.
Publication TypeJournal Article
Year of Publication2014
AuthorsHeijink, IH, Nawijn, MC, Hackett, T-L
JournalClin Exp Allergy
Volume44
Issue5
Pagination620-30
Date Published2014
ISSN1365-2222
KeywordsAnimals, Anti-Asthmatic Agents, Asthma, Cell Communication, Environmental Exposure, Epithelial Cells, Gene Expression Regulation, Genetic Predisposition to Disease, Humans, Respiratory Mucosa, Risk Factors
Abstract

The integrity of the airway epithelium in patients with asthma is often disrupted, with loss of epithelial cell-cell contacts. Airway epithelial barrier dysfunction may have important implications for asthma, because structural epithelial barrier function is tightly interwoven with the ability of the epithelium to regulate the immune system. We propose that changes at the airway epithelial barrier play a central role in the sensitisation to allergens and pathogenesis of allergic asthma. Many of the recently identified susceptibility genes for asthma are expressed in airway epithelium. However, the exact mechanisms by which the expression of epithelial susceptibility genes translates into a functionally altered response to aeroallergens in asthma are still unknown. In this review, we will focus on the role of airway epithelial barrier function in the susceptibility to develop allergic asthma and discuss therapeutic strategies aimed at the epithelial barrier.

DOI10.1111/cea.12296
Alternate JournalClin. Exp. Allergy
PubMed ID24612268